The Data Management &Biostatistics Core (DMBC) will serve a key bridging function for the CIRNA, encompassing the fields of data management, clinical informatics and biostatistics. Developing a comprehensive approach will enable CIRNA investigators to utilize vast amounts of research and clinical data by creating unified data models, standardizing data interfaces, and capturing detailed """"""""metadata"""""""" for investigators'research projects. The members of the DMBC have demonstrated their ability to manage large-scale smoking cessation and neuroimaging projects, and to incorporate rigorous quality assurance procedures that ensure integrity, security and privacy of data.
The specific aims of the DMBC are: (1) To design and maintain a distributed data management system for CIRNA projects;(2) To create and maintain a data repository of genotypic and phenotypic data to facilitate cross-project analyses and data sharing within and outside the CIRNA;(3) To provide biostatistical support to CIRNA investigators;and (4) To develop new statistical methodologies in addiction research. This centralized strategy will increase efficiency and reduce the cost of undertaking the individual research projects.
|Ashare, Rebecca L; Lerman, Caryn; Cao, Wen et al. (2016) Nicotine withdrawal alters neural responses to psychosocial stress. Psychopharmacology (Berl) 233:2459-67|
|Forcelli, Patrick A; Turner, Jill R; Lee, Bridgin G et al. (2016) Anxiolytic- and antidepressant-like effects of the methadone metabolite 2-ethyl-5-methyl-3,3-diphenyl-1-pyrroline (EMDP). Neuropharmacology 101:46-56|
|Schnoll, Robert A; Hitsman, Brian; Blazekovic, Sonja et al. (2016) Longitudinal changes in smoking abstinence symptoms and alternative reinforcers predict long-term smoking cessation outcomes. Drug Alcohol Depend 165:245-52|
|Strasser, Andrew A; Souprountchouk, Valentina; Kaufmann, Amanda et al. (2016) Nicotine Replacement, Topography, and Smoking Phenotypes of E-cigarettes. Tob Regul Sci 2:352-362|
|Perkins, Kenneth A; Karelitz, Joshua L; Michael, Valerie C et al. (2016) Initial Evaluation of Fenofibrate for Efficacy in Aiding Smoking Abstinence. Nicotine Tob Res 18:74-8|
|Ashare, R L; Kimmey, B A; Rupprecht, L E et al. (2016) Repeated administration of an acetylcholinesterase inhibitor attenuates nicotine taking in rats and smoking behavior in human smokers. Transl Psychiatry 6:e713|
|Lee, Bridgin G; Anastasia, Agustin; Hempstead, Barbara L et al. (2015) Effects of the BDNF Val66Met Polymorphism on Anxiety-Like Behavior Following Nicotine Withdrawal in Mice. Nicotine Tob Res 17:1428-35|
|Falcone, M; Bansal-Travers, M; Sanborn, P M et al. (2015) Awareness of FDA-mandated cigarette packaging changes among smokers of 'light' cigarettes. Health Educ Res 30:81-6|
|Jhanjee, Sonali; Jain, Raka; Jain, Veena et al. (2015) Evaluating the Effects of Varenicline on Craving, Withdrawal, and Affect in a Randomized, Double-Blind, Placebo-Controlled Clinical Trial of Varenicline for Smokeless Tobacco Dependence in India. J Psychoactive Drugs 47:325-30|
|Jain, Raka; Jhanjee, Sonali; Jain, Veena et al. (2015) Biochemical Validation of Self-Reported Smokeless Tobacco Abstinence among Smokeless Tobacco Users: Results from a Clinical Trial of Varenicline in India. J Psychoactive Drugs 47:331-5|
Showing the most recent 10 out of 104 publications