Breast cancer is the most common cancer among Hispanic women in the United States (US). The incidence of breast cancer among Hispanics (83.5 per 100,000) is lower than that among non-Hispanic Whites (147.3 per 100,000);however, as Hispanic women adopt the practices of mainstream US culture, their risk for breast cancer increases. Further, Hispanic women are at increased risk for breast cancers with poor prognosis. The overarching theme of this PSO application is to understand and prevent pre-cursors of breast cancer and to reduce breast cancer morbidity and mortality among Latinas. This will be done at multiple levels and will engage researchers across several disciplines. Projects have been carefully designed to contribute understanding to and preventing breast cancer in Latinas. It is the lonq-term goal of this PSO application to understand the antecedents of breast cancer in the Latina population, to understand the types of breast cancer found in the Latina population, and develop and implement a comprehensive program of screening to increase the opportunities for early breast cancer detection among Latinas. Our short-term obiectives are to: 1. Increase breast cancer screening among age-eligible Latinas; 2. Understand the processes by which ancestry, BMI, inflammation, and breast cancer are related in Latinas 3. To understand aspects of the etiology of poor prognosis breast cancers by identifying risk factors related to triple negative (TN) and HER-2-overexpressing (H2E) tumors, which are more commonly found in Latinas compared to non-Hispanic whites 4. To understand the role of ancestry in breast cancer antecedents and incidence among Latinas. 5. To explore expression of genes involved in tumor-related pathways signaling. This application is committed to a comprehensive multi-level approach to reducing health disparities. Its projects range from the biologic and genetic to the social context within which people live. Through its four projects and cores, the proposed Center will cover a myriad of aspects of breast cancer, from biological processes and genetic pathways to individual determinants and social determinants of breast cancer.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
5P50CA148143-05
Application #
8725067
Study Section
Special Emphasis Panel (ZCA1-SRLB-3 (J1))
Program Officer
Srinivasan, Shobha
Project Start
2010-05-01
Project End
2015-04-30
Budget Start
2014-05-01
Budget End
2015-04-30
Support Year
5
Fiscal Year
2014
Total Cost
$1,696,555
Indirect Cost
$531,394
Name
Fred Hutchinson Cancer Research Center
Department
Type
DUNS #
078200995
City
Seattle
State
WA
Country
United States
Zip Code
98109
Scheel, John R; Tillack, Allison A; Mercer, Lauren et al. (2018) Mobile Versus Fixed Facility: Latinas' Attitudes and Preferences for Obtaining a Mammogram. J Am Coll Radiol 15:19-28
Baglia, Michelle L; Cook, Linda S; Mei-Tzu, C et al. (2018) Alcohol, smoking, and risk of Her2-overexpressing and triple-negative breast cancer relative to estrogen receptor-positive breast cancer. Int J Cancer 143:1849-1857
Glassgow, Anne Elizabeth; Molina, Yamile; Kim, Sage et al. (2018) A Comparison of Different Intensities of Patient Navigation After Abnormal Mammography. Health Promot Pract :1524839918782168
Molina, Yamile; Kim, Sage J; Berrios, Nerida et al. (2018) Patient Navigation Improves Subsequent Breast Cancer Screening After a Noncancerous Result: Evidence from the Patient Navigation in Medically Underserved Areas Study. J Womens Health (Larchmt) 27:317-323
Molina, Yamile; Glassgow, Anne E; Kim, Sage J et al. (2017) Patient Navigation in Medically Underserved Areas study design: A trial with implications for efficacy, effect modification, and full continuum assessment. Contemp Clin Trials 53:29-35
Santiago-Torres, M; De Dieu Tapsoba, J; Kratz, M et al. (2017) Genetic ancestry in relation to the metabolic response to a US versus traditional Mexican diet: a randomized crossover feeding trial among women of Mexican descent. Eur J Clin Nutr 71:395-401
Molina, Yamile; Beresford, Shirley A A; Thompson, Beti (2017) Psychological Outcomes After a False Positive Mammogram: Preliminary Evidence for Ethnic Differences Across Time. J Racial Ethn Health Disparities 4:123-133
Molina, Yamile; Beresford, Shirley A A; Hayes Constant, Tara et al. (2017) Conversations about Abnormal Mammograms on Distress and Timely Follow-up Across Ethnicity. J Cancer Educ 32:320-327
Molina, Yamile; Plascak, Jesse J; Patrick, Donald L et al. (2017) Neighborhood Predictors of Mammography Barriers Among US-Based Latinas. J Racial Ethn Health Disparities 4:233-242
Thompson, Beti; Carosso, Elizabeth A; Jhingan, Esther et al. (2017) Results of a randomized controlled trial to increase cervical cancer screening among rural Latinas. Cancer 123:666-674

Showing the most recent 10 out of 54 publications