This project addresses our Center for Populafion Health and Health Disparities (CPHHD) application's overarching theme of understanding and preventing breast cancer precursors, morbidity, and mortality among Latinas by aiming to better understand the underlying biology of breast cancer in these women. Disparities in breast cancer survival befi^'een racial and ethnic groups have some well-documented social and economic causes. It is possible that differences in tumor biology between groups also contribute to differences in breast cancer outcomes. Recent gene expression profiling of breast cancer has deepened our understanding of this very heterogeneous disease and led to a new paradigm for the development of subtypespecific therapies and prevenfion strategies. However, the gene expression subtyping of breast cancer is based entirely on data generated by studies of non-Hispanic white women. The disparity created by the lack of biological data In minority women will continue to impede the implementafion of new approaches to prevention and treatment in these diverse populafions. As new treatments directed at specific subtypes become available it is essential that expression data from Hispanic women is also available?both to identify associations specific to Hispanic women and to assess the relevance of data generated in studies of non-Hispanic women. To better understand the biological subtypes of breast cancer in Hispanic women and the relationship of genetics and environmental influences (risk factors) to the development of specific breast tumor subtypes, we will conduct a study of 615 Hispanic women based primarily on the breast cancer cases outlined in Project 3. Our primary aim is to: 1. Determine the relationship between tumor subtype and ancestry in Hispanic women with breast cancer. This will be accomplished by: a) determining the tumor subtype by gene expression array b) determining ancestry through ancestry informafive markers (AIMs) c) comparing tumor subtype with individual ancestry as defined through the AIMs. Our secondary aims are to 2. Explore the relationship between established risk factors and breast tumor subtypes in Hispanic women. 3. Explore expression of genes involved in tumor-associated pathways in the tumors of Hispanic women and the relationship of these pathways with ancestry and risk factors.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
5P50CA148143-05
Application #
8725071
Study Section
Special Emphasis Panel (ZCA1-SRLB-3)
Project Start
Project End
Budget Start
2014-05-01
Budget End
2015-04-30
Support Year
5
Fiscal Year
2014
Total Cost
$201,405
Indirect Cost
Name
Fred Hutchinson Cancer Research Center
Department
Type
DUNS #
078200995
City
Seattle
State
WA
Country
United States
Zip Code
98109
Molina, Yamile; Hempstead, Bridgette H; Thompson-Dodd, Jacci et al. (2015) Medical Advocacy and Supportive Environments for African-Americans Following Abnormal Mammograms. J Cancer Educ 30:447-52
Molina, Yamile; Lehavot, Keren; Beadnell, Blair et al. (2014) Racial Disparities in Health Behaviors and Conditions Among Lesbian and Bisexual Women: The Role of Internalized Stigma. LGBT Health 1:131-139
Coronado, Gloria D; Gutierrez, Javiera Martinez; Jhingan, Esther et al. (2014) Patient and clinical perspectives on changes to mammography screening guidelines. Breast J 20:105-6
Coronado, Gloria D; Jimenez, Ricardo; Martinez-Gutierrez, Javiera et al. (2014) Multi-level Intervention to increase participation in mammography screening: ¬°Fortaleza Latina! study design. Contemp Clin Trials 38:350-4
Molina, Yamile; Hohl, Sarah D; Ko, Linda K et al. (2014) Understanding the patient-provider communication needs and experiences of Latina and non-Latina White women following an abnormal mammogram. J Cancer Educ 29:781-9
Molina, Yamile; Yi, Jean C; Martinez-Gutierrez, Javiera et al. (2014) Resilience among patients across the cancer continuum: diverse perspectives. Clin J Oncol Nurs 18:93-101
Molina, Yamile; Kim, Sage; Berrios, Nerida et al. (2014) Medical mistrust and patient satisfaction with mammography: the mediating effects of perceived self-efficacy among navigated African American women. Health Expect :
Molina, Yamile; Beresford, Shirley A A; Espinoza, Noah et al. (2014) Psychological distress, social withdrawal, and coping following receipt of an abnormal mammogram among different ethnicities: a mediation model. Oncol Nurs Forum 41:523-32
Molina, Y; Ramirez-Valles, J (2013) HIV/AIDS stigma: measurement and relationships to psycho-behavioral factors in Latino gay/bisexual men and transgender women. AIDS Care 25:1559-68
Balsam, Kimberly F; Beadnell, Blair; Molina, Yamile (2013) The Daily Heterosexist Experiences Questionnaire: Measuring Minority Stress Among Lesbian, Gay, Bisexual, and Transgender Adults. Meas Eval Couns Dev 46:3-25

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