This project proposes to perform high-throughput cancer mutation profiling on 500 non-small cell lung cancer (NSCLC) specimens from White and African-American populations, with a view to testing the hypothesis that common somatic cancer mutations vary in frequency as a function of race. Specimens of FFPE NSCLC will be obtained from the VA Cancer Tissue Repository and Database site. DNA will be extracted and run on an expanded OncoMap platform, using the Sequenom mass-spectrometric genotyping technology. We will compare the frequencies of cancer causing and cancer susceptibility mutations by race, SES, gender and smoking status, utilizing CanCORS clinical and survey data associated with the NSCLC specimens. Achieving these objectives should establish a basis for definitive research regarding the interplay of somatic genetic and social contextual factors that influence cancer outcomes across populations.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
5P50CA148596-04
Application #
8495096
Study Section
Special Emphasis Panel (ZCA1-SRLB-3)
Project Start
Project End
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
4
Fiscal Year
2013
Total Cost
$198,227
Indirect Cost
$30,407
Name
Harvard University
Department
Type
DUNS #
149617367
City
Boston
State
MA
Country
United States
Zip Code
02115
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