The goal of this Core is to provide high quality clinical data and subject samples for use in the scientific projects of the SPORE. To provide these resources. Core A will utilize and expand upon clinical and biospecimen resources that already exist at each institution. For projects in which additional or different samples/data are required, prospective collection of these samples and their corresponding clinical information will be supported through Core A.

Public Health Relevance

Core A is essential to ensure that all research activities in this SPORE utilizing human samples are provided with sound clinical and pathological information, that the data are efficiently and accurately managed, and that distribution of samples and data occurs in a reliable and timely manner.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Specialized Center (P50)
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Special Emphasis Panel (ZCA1-RPRB-7)
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Ohio State University
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Cote, Gilbert J; Evers, Caitlin; Hu, Mimi I et al. (2017) Prognostic Significance of Circulating RET M918T Mutated Tumor DNA in Patients With Advanced Medullary Thyroid Carcinoma. J Clin Endocrinol Metab 102:3591-3599
Gudmundsson, Julius; Thorleifsson, Gudmar; Sigurdsson, Jon K et al. (2017) A genome-wide association study yields five novel thyroid cancer risk loci. Nat Commun 8:14517
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Bagheri-Yarmand, Rozita; Williams, Michelle D; Grubbs, Elizabeth G et al. (2017) ATF4 Targets RET for Degradation and Is a Candidate Tumor Suppressor Gene in Medullary Thyroid Cancer. J Clin Endocrinol Metab 102:933-941
Wang, Yanqiang; He, Huiling; Li, Wei et al. (2017) MYH9 binds to lncRNA gene PTCSC2 and regulates FOXE1 in the 9q22 thyroid cancer risk locus. Proc Natl Acad Sci U S A 114:474-479

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