Proposed is a Tobacco Center of Regulatory Science (TCORS) for Research Relevant to the Family Smoking Prevention and Tobacco Control Act (FSPTCA). The proposed Center will characterize combustible and non-combustible, conventional, new and manipulated nicotine/tobacco products and the impact of variations in those products on human behavior and exposure. The focus of the Center is the products and resulting human use behaviors and exposures, examined in crossover acute laboratory trials. Objective 1. To characterize the chemical profiles and physical properties of combustible, non-combustible, conventional, new and manipulated tobacco products (Project I and Core B). Objective 2. To differentiate the appeal and consumer acceptance of combustible tobacco products that differ only on a single characteristic of interest (e.g., menthol concentration, smok pH) (Project II). Objective 3. To explore tobacco microbial constituents and the oral microbiome of tobacco users (Project III). Objective 4. To support the data management and statistical needs of the Center, and provide FDA CTP/NIH and select other Centers with early access to the data. Objective 5. To train the next generation of transdisciplinary scientists in science to inform tobacco regulation. Objective 6. To expand the knowledge base through a rapid response system of developmental/pilot projects. The results of the proposed research will provide scientific data to inform the regulation of tobacco products by the FDA Center for Tobacco Products (CTP). The proposed Center will address, at a minimum, two research priorities: 1) """"""""Diversity of Tobacco Products - understanding the constituents, components, ingredients, additives, and design features;use behaviors"""""""";2)""""""""Adverse Health Consequences - understanding health risks of multiple tobacco types...""""""""

Public Health Relevance

In most studies, one can only examine a single dimension of tobacco harm. This is a proposal to simultaneously measure harm in three orthoganal contexts: toxicity, consumer accepance and liking, and bacterial exposure, providing a much clearer picture of where a product lies in a continuum of harm, and a scientific basis for regulation of particular product design features.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
5P50CA180523-02
Application #
8735104
Study Section
Special Emphasis Panel (ZRG1-BDCN-A (40))
Program Officer
Djordjevic, Mirjana V
Project Start
2013-09-18
Project End
2018-08-31
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
2
Fiscal Year
2014
Total Cost
$3,828,516
Indirect Cost
$646,689
Name
University of Maryland College Park
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
790934285
City
College Park
State
MD
Country
United States
Zip Code
20742
Chopyk, Jessica; Chattopadhyay, Suhana; Kulkarni, Prachi et al. (2017) Mentholation affects the cigarette microbiota by selecting for bacteria resistant to harsh environmental conditions and selecting against potential bacterial pathogens. Microbiome 5:22
Kim, Hyoshin; Davis, Andrew H; Dohack, Jaime L et al. (2017) E-Cigarettes Use Behavior and Experience of Adults: Qualitative Research Findings to Inform E-Cigarette Use Measure Development. Nicotine Tob Res 19:190-196
Weaver, Scott R; Kim, Hyoshin; Glasser, Allison M et al. (2017) Establishing consensus on survey measures for electronic nicotine and non-nicotine delivery system use: Current challenges and considerations for researchers. Addict Behav :
Smyth, Eoghan M; Kulkarni, Prachi; Claye, Emma et al. (2017) Smokeless tobacco products harbor diverse bacterial microbiota that differ across products and brands. Appl Microbiol Biotechnol 101:5391-5403
Chopyk, Jessica; Chattopadhyay, Suhana; Kulkarni, Prachi et al. (2017) Temporal Variations in Cigarette Tobacco Bacterial Community Composition and Tobacco-Specific Nitrosamine Content Are Influenced by Brand and Storage Conditions. Front Microbiol 8:358
Kim, Hyoshin; Brinkman, Marielle C; Sharma, Eva et al. (2016) Variability in Puff Topography and Exhaled CO in Waterpipe Tobacco Smoking. Tob Regul Sci 2:301-308
Kim, Hyoshin; Lim, Juyun; Buehler, Stephanie S et al. (2016) Role of sweet and other flavours in liking and disliking of electronic cigarettes. Tob Control 25:ii55-ii61
Crenshaw, Michael D; Tefft, Margaret E; Buehler, Stephanie S et al. (2016) Determination of nicotine, glycerol, propylene glycol and water in electronic cigarette fluids using quantitative (1) H NMR. Magn Reson Chem 54:901-904
Brinkman, Marielle C; Kim, Hyoshin; Gordon, Sydney M et al. (2016) Design and Validation of a Research-Grade Waterpipe Equipped With Puff Topography Analyzer. Nicotine Tob Res 18:785-93
Klupinski, Theodore P; Strozier, Erich D; Friedenberg, David A et al. (2016) Identification of New and Distinctive Exposures from Little Cigars. Chem Res Toxicol 29:162-8

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