Prevention investigators in our Center and elsewhere have demonstrated that drug abuse prevention efficacy can be significantly enhanced by targeting individuals who are most vulnerable to developing problems and tailoring message content and format based on the characteristics of these individuals. Our previous work focused on drug use initiation and identified behavioral mechanisms (neurobehavioral response to reinforcing, novel and emotional stimuli) whereby the sensation seeking dimension of impulsivity is associated with vulnerability to drug use initiation and high sensation-value contexts enhance the efficacy of prevention interventions designed to reduce drug use initiation. Further development of laboratory models to identify individuals who are vulnerable to drug use escalation and development of associated problems and identifying the characteristics of these individuals that predispose them to vulnerability and/or influence the efficacy of targeted intervention materials is of critical importance for informing and advancing the field of drug abuse prevention. This application proposes five years of research to continue laboratory investigations of individual differences associated with drug use escalation and associated exposure to heavy drug use. Growing evidence suggests that vulnerability to drug-use escalation is associated with self-control mechanisms. A multidisciplimary approach combining personality measurement with laboratory abuse liability assessment, behavioral inhibition task performance and brain imaging methodologies will be used to examine impulsivity among matched groups of tobacco and marijuana users who have either maintained stable patterns of intermittent/light use (escalation resistant) or who have escalated to heavy use with and without extended histories of heavy use (escalation;escalation + extended drug exposure) to test the hypothesis that drug use escalation is associated with inhibitory neurobehavioral dimensions of impulsivity. Knowledge of the association between component dimensions of impulsivity and drug-use escalation will enhance understanding of vulnerability to and consequences of drug use escalation and thus our ability to design more efficacious tailored and targeted drug abuse prevention interventions.

Public Health Relevance

Drug abuse prevention efficacy is improved by targeting at-risk individuals and tailoring interventions based on the characteristics of those individuals. Impulsivity is closely linked with drug abuse vulnerability. This project will support prevention science by identifying the neurobehavioral dimensions of impulsivity that are associated with vulnerability to and adverse consequences of tobacco and marijuana use escalation.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Specialized Center (P50)
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Special Emphasis Panel (ZDA1-EXL-T (02))
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University of Kentucky
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Chester, David S; DeWall, C Nathan (2014) Prefrontal recruitment during social rejection predicts greater subsequent self-regulatory imbalance and impairment: neural and longitudinal evidence. Neuroimage 101:485-93
Derefinko, Karen J; Hayden, Angela; Sibley, Margaret H et al. (2014) A Story Mapping Intervention to Improve Narrative Comprehension Deficits in Adolescents with ADHD. School Ment Health 6:251-263
Hofford, Rebecca S; Darna, Mahesh; Wilmouth, Carrie E et al. (2014) Environmental enrichment reduces methamphetamine cue-induced reinstatement but does not alter methamphetamine reward or VMAT2 function. Behav Brain Res 270:151-8
Roberts, Walter; Peters, Jessica R; Adams, Zachary W et al. (2014) Identifying the facets of impulsivity that explain the relation between ADHD symptoms and substance use in a nonclinical sample. Addict Behav 39:1272-7
Nakhnikian, Alexander; Rebec, George V; Grasse, Leslie M et al. (2014) Behavior modulates effective connectivity between cortex and striatum. PLoS One 9:e89443
Zimmerman, Rick S; Cupp, Pamela K; Abadi, Melissa et al. (2014) The effects of framing and fear on ratings and impact of antimarijuana PSAs. Subst Use Misuse 49:824-35
Luo, Yi; Wu, Tingting; Broster, Lucas S et al. (2014) The temporal course of the influence of anxiety on fairness considerations. Psychophysiology 51:834-42
Martin, Catherine Anne; Lile, Joshua; Guenthner, Greg et al. (2014) Behavioral effects of modafinil and nicotine, alone and in combination, in tobacco-deprived young adult smokers. J Clin Psychopharmacol 34:278-81
Sunsay, Ceyhun; Rebec, George V (2014) Extinction and reinstatement of phasic dopamine signals in the nucleus accumbens core during Pavlovian conditioning. Behav Neurosci 128:579-87
Derefinko, Karen J; Peters, Jessica R; Eisenlohr-Moul, Tory A et al. (2014) Relations between trait impulsivity, behavioral impulsivity, physiological arousal, and risky sexual behavior among young men. Arch Sex Behav 43:1149-58

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