The Clinical Core is the operational hub of the Center. It is integral to collecting the data necessary for satisfying centerwide aims as well as the specific aims of each research module. The Clinical Core also conducts the psychiatric diagnostic evaluations of all members of the nuclear family (N= 775 families) consisting of the proband father, his spouse, and has biological and stepchildren. Step-parents are also diagnostically evaluated. In addition, this Core performs medical and dental examinations of the children and administers the research protocols to each family member, including collection of biological specimens (blood, saliva, skin, urine) for timely distribution to various laboratories. The Clinical Core ensures compliance with the University of Pittsburgh IRB, HIPPA, and NIH regulations. While primarily responsible for operational support of the Center's scientific activities, faculty in this Core are also integrally involved in empirical research. Accordingly, recent publications have focused on diverse topics, including the role of orodental health on SUD development, suicidality, sexual behavior and STD's, mortality, and health and psychiatric comorbidity.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Specialized Center (P50)
Project #
5P50DA005605-20
Application #
8237019
Study Section
Special Emphasis Panel (ZDA1)
Project Start
Project End
Budget Start
2011-03-01
Budget End
2012-02-29
Support Year
20
Fiscal Year
2011
Total Cost
$451,166
Indirect Cost
Name
University of Pittsburgh
Department
Type
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Halliburton, Amanda E; Ridenour, Ty A; White, Bradley A et al. (2017) Clinically differentiating life-course-persistent and adolescence-limited conduct problems: Is age-of-onset really enough? J Appl Dev Psychol 52:34-45
Bastian, Jaime R; Chen, Huijun; Zhang, Hongfei et al. (2017) Dose-adjusted plasma concentrations of sublingual buprenorphine are lower during than after pregnancy. Am J Obstet Gynecol 216:64.e1-64.e7
Eckert, Scott; Feingold, Eleanor; Cooper, Margaret et al. (2017) Variants on chromosome 4q21 near PKD2 and SIBLINGs are associated with dental caries. J Hum Genet 62:491-496
Harty, Seth C; Gnagy, Elizabeth M; Pelham Jr, William E et al. (2017) Anger-irritability as a mediator of attention deficit hyperactivity disorder risk for adolescent alcohol use and the contribution of coping skills. J Child Psychol Psychiatry 58:555-563
Rabinowitz, Jill A; Osigwe, Ijeoma; Byrne, Ashley et al. (2017) Father- and Youth-Reported Family Affective Expression Differentially Predicts Youth Internalizing and Externalizing Symptoms. J Clin Child Adolesc Psychol :1-14
Rabinowitz, Jill A; Osigwe, Ijeoma; Drabick, Deborah A G et al. (2016) Negative emotional reactivity moderates the relations between family cohesion and internalizing and externalizing symptoms in adolescence. J Adolesc 53:116-126
Vanyukov, Michael M; Tarter, Ralph E; Conway, Kevin P et al. (2016) Risk and resistance perspectives in translation-oriented etiology research. Transl Behav Med 6:44-54
Altszuler, Amy R; Page, Timothy F; Gnagy, Elizabeth M et al. (2016) Financial Dependence of Young Adults with Childhood ADHD. J Abnorm Child Psychol 44:1217-29
Rabinowitz, Jill A; Drabick, Deborah A G; Reynolds, Maureen D et al. (2016) Child Temperamental Flexibility Moderates the Relation between Positive Parenting and Adolescent Adjustment. J Appl Dev Psychol 43:43-53
Molina, Brooke S G; Gnagy, Elizabeth M; Joseph, Heather M et al. (2016) Antisocial Alcoholism in Parents of Adolescents and Young Adults With Childhood ADHD. J Atten Disord :

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