The overarching goal of the Developmental Psychopathology Module is to elucidate the psychopathological precursors and concomitants of substance use disorder (SUD) and their ontogenetic connections. Building on extensive research conducted to date, we propose in the next 5 years to prospectively examine the influences on developmentally specific manifestations of psychological dysregulation and adulthood SUD outcomes. Among characteristics manifested as psychopathology in childhood and adolescence, disruptive behavior disorders have been demonstrated most clearly to predispose to illicit drug use and SUD. Using contemporary psychometric methods, the project will develop a construct indicated by childhood disruptive behavior disorder symptoms, termed Behavioral Undercontrol (BU). This construct is conceptualized as reflecting a persistent trait with developmentally specific manifestations. The indicators of this dimension are collected from parents as well as offspring, and transmission of BU from parent to child will be studied. The research will identify psychopathological precursors of SUD in late childhood and adolescence, and will determine the mediating and moderating influences in the transition from adolescence to adulthood that portend SUD diagnoses resulting from illicit drug use. The Module will determine the influences of BU, in the context of parenting practices and peer selection, on adolescent substance use trajectories and SUDs. In young adulthood, we will examine frontal white matter organization as a neuromaturation outcome indicator. We will examine the influence of frontal white matter organization on laboratory indicators of decision-making competence. We hypothesize that childhood BU and adolescent substance use will predict white matter dysmaturation and associated deficits in decision-making competence in young adulthood, leading to severe and persistent SUDs consequent to illicit drugs.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Specialized Center (P50)
Project #
5P50DA005605-23
Application #
8646896
Study Section
Special Emphasis Panel (ZDA1-EXL-T)
Project Start
Project End
Budget Start
2014-03-01
Budget End
2015-02-28
Support Year
23
Fiscal Year
2014
Total Cost
$232,618
Indirect Cost
$54,289
Name
University of Pittsburgh
Department
Type
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Cochran, Gerald; Gordon, Adam J; Field, Craig et al. (2016) Developing a framework of care for opioid medication misuse in community pharmacy. Res Social Adm Pharm 12:293-301
Babinski, Dara E; Pelham Jr, William E; Molina, Brooke S G et al. (2016) Maternal ADHD, Parenting, and Psychopathology Among Mothers of Adolescents With ADHD. J Atten Disord 20:458-68
Schwantes-An, Tae-Hwi; Zhang, Juan; Chen, Li-Shiun et al. (2016) Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts. Behav Genet 46:151-69
Rabinowitz, Jill A; Drabick, Deborah A G; Reynolds, Maureen D (2016) Youth Withdrawal Moderates the Relationhips Between Neighborhood Factors and Internalizing Symptoms in Adolescence. J Youth Adolesc 45:427-39
Altszuler, Amy R; Page, Timothy F; Gnagy, Elizabeth M et al. (2016) Financial Dependence of Young Adults with Childhood ADHD. J Abnorm Child Psychol 44:1217-29
Rabinowitz, Jill A; Osigwe, Ijeoma; Drabick, Deborah A G et al. (2016) Negative emotional reactivity moderates the relations between family cohesion and internalizing and externalizing symptoms in adolescence. J Adolesc 53:116-126
Vanyukov, Michael M; Tarter, Ralph E; Conway, Kevin P et al. (2016) Risk and resistance perspectives in translation-oriented etiology research. Transl Behav Med 6:44-54
Cornelius, Jack R; Chung, Tammy; Douaihy, Antoine B et al. (2016) Mirtazapine in comorbid major depression and an alcohol use disorder: A double-blind placebo-controlled pilot trial. Psychiatry Res 242:326-30
Rabinowitz, Jill A; Drabick, Deborah A G; Reynolds, Maureen D et al. (2016) Child Temperamental Flexibility Moderates the Relation between Positive Parenting and Adolescent Adjustment. J Appl Dev Psychol 43:43-53
Bastian, Jaime R; Chen, Huijun; Zhang, Hongfei et al. (2016) Dose-adjusted plasma concentrations of sublingual buprenorphine are lower during than after pregnancy. Am J Obstet Gynecol :

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