The establishment of the Medical University of South Carolina (MUSC) SCOR in 2002 provided a critical impetus to engage the research community in more sex and gender-based research. MUSC had strength in translational, interdisciplinary research addictions, but no sex or gender-specific focus. In addition, the SCOR was the first women's health research initiative on the MUSC campus. The visible, campus-wide collaborations of SCOR Investigators, combined with the Institutional support of the SCOR pilot project program have considerably increased sex and gender-based research. Close collaboration with the MUSC BIRCWH program, awarded in 2007, further enhanced campus-wide, interdisciplinary collaborations focused on women's health. We have begun collaborations with SCOR programs at other universities in order to maximize the scientific output from the ORWH investment in the SCOR initiative by sharing resources and combining data. During the renewal period, our core scientific projects will continue to focus on sex and gender differences in the relationship between addiction and stress response using emerging technology in closely aligned clinical and basic science projects. The overarching goals of the center will focus on supporting and Improving the translational scientific collaborations of the core and pilot research projects, catalyzing further growth of interdisciplinary sex and gender-based research on the MUSC campus and creating strategic partnerships to enhance the translation and dissemination of SCOR findings and other relevant research to improve the health of women and girls. Center funding has allowed us to: 1) increase interdisciplinary sex and gender-based research on the MUSC campus, 2) bring together institutional and scientific leadership to form a high visibility operational unit focused on research In women's health, 3) establish infrastructure to support efficient operations, integration, and stability, 4) coalesce a group of senior investigatos to integrate their scientific expertise and research skills to advance sex and gender-based research, 5) attract and train new and junior investigators in sex and gender-based research, 6) support the development and testing of innovative ideas and new technology, and 7) provide a supportive training environment for basic and clinical researchers interested In sex and gender-based research. The next funding period will allow us to build on these accomplishments, expand our research program utilizing innovative techniques and novel compounds, increase cross-SCOR collaborations, enhance outreach and dissemination efforts, and attract new investigators. Our SCOR, with a truly interdisciplinary and translational focus on sex and gender Issues in addictions and stress response, is prepared to work collaboratively with other SCOR colleagues towards the vision, goals, and objectives outlined In the 2010 ORWH Strategic Plan.

Public Health Relevance

The MUSC SCOR coalesces Investigators across different disciplines working closely together to explore sex and gender differences in addictions and the relationship between stress and drug use. This project catalyzes further growth of Interdisciplinary sex and gender-based research on the MUSC campus and creates strategic partnerships to enhance the translation and dissemination of SCOR findings and other relevant research to improve women's health.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Specialized Center (P50)
Project #
Application #
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Wetherington, Cora Lee
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Medical University of South Carolina
Schools of Medicine
United States
Zip Code
Cason, Angie M; Kohtz, Amy; Aston-Jones, Gary (2016) Role of Corticotropin Releasing Factor 1 Signaling in Cocaine Seeking during Early Extinction in Female and Male Rats. PLoS One 11:e0158577
Glover, Elizabeth J; McDougle, Molly J; Siegel, Griffin S et al. (2016) Role for the Rostromedial Tegmental Nucleus in Signaling the Aversive Properties of Alcohol. Alcohol Clin Exp Res 40:1651-61
Allen, Alicia M; McRae-Clark, Aimee L; Carlson, Samantha et al. (2016) Determining menstrual phase in human biobehavioral research: A review with recommendations. Exp Clin Psychopharmacol 24:1-11
Brady, Kathleen T; McCauley, Jenna L; Back, Sudie E (2016) Prescription Opioid Misuse, Abuse, and Treatment in the United States: An Update. Am J Psychiatry 173:18-26
Moran-Santa Maria, M M; Baker, N L; McRae-Clark, A L et al. (2016) Effects of yohimbine and drug cues on impulsivity and attention in cocaine-dependent men and women and sex-matched controls. Drug Alcohol Depend 162:56-63
Tomko, Rachel L; Bountress, Kaitlin E; Gray, Kevin M (2016) Personalizing substance use treatment based on pre-treatment impulsivity and sensation seeking: A review. Drug Alcohol Depend 167:1-7
Leong, Kah-Chung; Zhou, Luyi; Ghee, Shannon M et al. (2016) Oxytocin decreases cocaine taking, cocaine seeking, and locomotor activity in female rats. Exp Clin Psychopharmacol 24:55-64
Leong, Kah-Chung; Berini, Carole R; Ghee, Shannon M et al. (2016) Extended cocaine-seeking produces a shift from goal-directed to habitual responding in rats. Physiol Behav 164:330-5
Smith, Philip H; Kasza, Karin A; Hyland, Andrew et al. (2015) Gender differences in medication use and cigarette smoking cessation: results from the International Tobacco Control Four Country Survey. Nicotine Tob Res 17:463-72
Weinberger, Andrea H; Smith, Philip H; Allen, Sharon S et al. (2015) Systematic and meta-analytic review of research examining the impact of menstrual cycle phase and ovarian hormones on smoking and cessation. Nicotine Tob Res 17:407-21

Showing the most recent 10 out of 90 publications