Oregon is one of a few states where methamphetamine (MA) abusers without a greater history of cocaine abuse are recruited for clinical research. This renewal of the Methamphetamine Abuse Research Center (MARC) will characterize effects of MA at molecular, genetic, neurochemical, anatomical, behavioral, and clinical levels, to identify risks and obstacles to recovery in MA abusers. Integrated preclinical and clinical research components use some common methodologies and address MA-related themes of neuroadaptation, neurocircuitry, and neuroimmune effects. This renewal continues to pursue bidirectional translational research in which human and animal results inform one another. The Center's Administrative Core 1 supervises budgetary issues and facilitates interactions among MARC investigators, and the Biostatistics and Genetics Core 2 provides statistical and genetic analysis services. The Animal Core 3 provides genetic animal models and some behavioral testing services to MARC investigators. The Education Core 4 coordinates the research training of M.D. and Ph.D. pre- and post-doctoral fellows, and disseminates clinical and preclinical information from MARC investigators to other Centers and more rural areas that are impacted by MA abuse. The Translational Service Core 5 recruits and characterizes subjects and conducts identical biochemical assays on human and MA drinking selected mouse line samples. The Pilot Projects Core 6 supports the development of multiple new directions in research on MA abuse. Scientific Component 7 associates image analysis results with impulsive decision making in human and animal subjects. Scientific Component 8 examines the role of immune function in human cognitive response and tests a novel immunotherapy in mice, and Scientific Component 9 uses MA drinking selected mouse lines to examine the role of immune function in the risk for MA self-administration and how this risk interacts with MA effects on immune function. Data and samples are shared and compared across components. Thus, the MARC addresses clinically relevant themes using integrated, innovative, multidisciplinary, and translational approaches.

Public Health Relevance

Recent studies indicate that the medical, social, legal, and occupational costs of MA abuse are over $2 billion dollars a year. This Methamphetamine Abuse Research Center will characterize medical, psychiatric, and genetic factors that contribute to MA abuse and impede recovery from drug withdrawal.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Specialized Center (P50)
Project #
5P50DA018165-08
Application #
8693982
Study Section
Special Emphasis Panel (ZDA1)
Program Officer
Grant, Steven J
Project Start
2004-09-01
Project End
2017-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
8
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Oregon Health and Science University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
City
Portland
State
OR
Country
United States
Zip Code
97239
Ford 2nd, James H; Abraham, Amanda J; Lupulescu-Mann, Nicoleta et al. (2017) Promoting Adoption of Medication for Opioid and Alcohol Use Disorders Through System Change. J Stud Alcohol Drugs 78:735-744
Eastwood, Emily C; Eshleman, Amy J; Janowsky, Aaron et al. (2017) Verification of a genetic locus for methamphetamine intake and the impact of morphine. Mamm Genome :
Pizzimenti, Christie L; Navis, Tom M; Lattal, K Matthew (2017) Persistent effects of acute stress on fear and drug-seeking in a novel model of the comorbidity between post-traumatic stress disorder and addiction. Learn Mem 24:422-431
Wilhelm, Clare J; Fuller, Bret E; Huckans, Marilyn et al. (2017) Peripheral immune factors are elevated in women with current or recent alcohol dependence and associated with altered mood and memory. Drug Alcohol Depend 176:71-78
Miner, Nicholas B; Elmore, Josh S; Baumann, Michael H et al. (2017) Trace amine-associated receptor 1 regulation of methamphetamine-induced neurotoxicity. Neurotoxicology 63:57-69
Li, Ming-Hua; Underhill, Suzanne M; Reed, Cheryl et al. (2017) Amphetamine and Methamphetamine Increase NMDAR-GluN2B Synaptic Currents in Midbrain Dopamine Neurons. Neuropsychopharmacology :
Miner, Nicholas B; O'Callaghan, James P; Phillips, Tamara J et al. (2017) The combined effects of 3,4-methylenedioxymethamphetamine (MDMA) and selected substituted methcathinones on measures of neurotoxicity. Neurotoxicol Teratol 61:74-81
Eshleman, Amy J; Wolfrum, Katherine M; Reed, John F et al. (2017) Structure-Activity Relationships of Substituted Cathinones, with Transporter Binding, Uptake, and Release. J Pharmacol Exp Ther 360:33-47
Greenberg, Gian D; Phillips, Tamara J; Crabbe, John C (2016) Effects of acute alcohol withdrawal on nest building in mice selectively bred for alcohol withdrawal severity. Physiol Behav 165:257-66
Abraham, Antony D; Neve, Kim A; Lattal, K Matthew (2016) Activation of D1/5 Dopamine Receptors: A Common Mechanism for Enhancing Extinction of Fear and Reward-Seeking Behaviors. Neuropsychopharmacology 41:2072-81

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