The Biostatistics and Genetics Core (BGC) Component 2 will provide data processing, database coordination and maintenance, data analysis and statistical support for each of the other cores and projects within the Methamphetamine Abuse Research Center (MARC). Quantitative genetic analysis support will also be given to those Cores using mouse genetic models. This single unit serves as an important interface for the transmission of diverse types of data and processed information among core and project investigators. It assures that data and information from different cores and projects will be processed uniformly and in such a way as to allow for their smooth interface where appropriate. The environment provided by a single data management and biostatistics unit also facilitates the effective and timely return of processed data and information to the core and project investigators in support of their objectives. In addition, this Core will facilitate data sharing for investigators within and outside the center. This Core will continue to assist in the use of public databases and computer software, and provide the computer infrastructure for the microarray and QTL studies. Training in statistical and genetic methods and experimental design will also be provided on a one-on-one and as-needed basis. This Core will also develop new analytical programs tailored to the needs of MARC investigators, particularly newer clustering algorithms. As the Center continues to evolve, we will continue development of a central data warehouse for the MARC on our secure server.

Public Health Relevance

This Core supports the scientific activities of almost all other Cores and Components of the MARC, thus relevance stems from the impact of these other MARC units on the future mitigation or treatment of methamphetamine abuse in human drug abuse populations.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Specialized Center (P50)
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Special Emphasis Panel (ZDA1)
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Oregon Health and Science University
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Ford 2nd, James H; Abraham, Amanda J; Lupulescu-Mann, Nicoleta et al. (2017) Promoting Adoption of Medication for Opioid and Alcohol Use Disorders Through System Change. J Stud Alcohol Drugs 78:735-744
Eastwood, Emily C; Eshleman, Amy J; Janowsky, Aaron et al. (2017) Verification of a genetic locus for methamphetamine intake and the impact of morphine. Mamm Genome :
Pizzimenti, Christie L; Navis, Tom M; Lattal, K Matthew (2017) Persistent effects of acute stress on fear and drug-seeking in a novel model of the comorbidity between post-traumatic stress disorder and addiction. Learn Mem 24:422-431
Wilhelm, Clare J; Fuller, Bret E; Huckans, Marilyn et al. (2017) Peripheral immune factors are elevated in women with current or recent alcohol dependence and associated with altered mood and memory. Drug Alcohol Depend 176:71-78
Miner, Nicholas B; Elmore, Josh S; Baumann, Michael H et al. (2017) Trace amine-associated receptor 1 regulation of methamphetamine-induced neurotoxicity. Neurotoxicology 63:57-69
Li, Ming-Hua; Underhill, Suzanne M; Reed, Cheryl et al. (2017) Amphetamine and Methamphetamine Increase NMDAR-GluN2B Synaptic Currents in Midbrain Dopamine Neurons. Neuropsychopharmacology :
Miner, Nicholas B; O'Callaghan, James P; Phillips, Tamara J et al. (2017) The combined effects of 3,4-methylenedioxymethamphetamine (MDMA) and selected substituted methcathinones on measures of neurotoxicity. Neurotoxicol Teratol 61:74-81
Eshleman, Amy J; Wolfrum, Katherine M; Reed, John F et al. (2017) Structure-Activity Relationships of Substituted Cathinones, with Transporter Binding, Uptake, and Release. J Pharmacol Exp Ther 360:33-47
Greenberg, Gian D; Phillips, Tamara J; Crabbe, John C (2016) Effects of acute alcohol withdrawal on nest building in mice selectively bred for alcohol withdrawal severity. Physiol Behav 165:257-66
Abraham, Antony D; Neve, Kim A; Lattal, K Matthew (2016) Activation of D1/5 Dopamine Receptors: A Common Mechanism for Enhancing Extinction of Fear and Reward-Seeking Behaviors. Neuropsychopharmacology 41:2072-81

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