The Pharmacogenetics CORE integrates molecular genetics into the design and execution of the drug administration and clinical trials of pharmacotherapies for cocaine and methamphetamine dependence. The CORE will provide DNA isolation and DNA genotyping of cocaine- or methamphetamine-dependent patients from ongoing and completed clinical pharmacotherapy trials. Genetic variants and copy number variants (CNVs) will be analyzed for significant associations with response to pharmacotherapeutic treatment regimes. DNA samples will be evaluated for associations of 1) single nucleotide polymorphisms (SNPs), 2) copy number variants (CNVs), and 3) insertion/deletion variants with response to pharmacotherapy. As indicated in our Preliminary Data, we have started the examination ofthe CNVs. Searches ofthe literature and of bioinformatic databases will be conducted to translate the findings about the genetic associations with pharmacological responses into human studies. Genes with significantly associated variants identified from the bioinformatic searches will then be used in prospective pharmacogenetic selection of patients for the matching of these patients to the most appropriate of many available potential anti-addiction medications for further placebo controlled testing in either human laboratory drug administration or clinical trial studies.

Public Health Relevance

The Pharmacogentics CORE will allow us to understand the genetic components that may influence a person's response to pharmacotherapy. The results of this research should allow the tailoring of treatment to each individual person.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Specialized Center (P50)
Project #
5P50DA018197-09
Application #
8379199
Study Section
Special Emphasis Panel (ZDA1-SXC-E)
Project Start
Project End
Budget Start
2012-06-01
Budget End
2013-05-31
Support Year
9
Fiscal Year
2012
Total Cost
$217,663
Indirect Cost
$61,702
Name
Baylor College of Medicine
Department
Type
DUNS #
051113330
City
Houston
State
TX
Country
United States
Zip Code
77030
Cao, Bo; Bauer, Isabelle E; Sharma, Ajaykumar N et al. (2016) Reduced hippocampus volume and memory performance in bipolar disorder patients carrying the BDNF val66met met allele. J Affect Disord 198:198-205
Shorter, Daryl; Nielsen, David A; Hamon, Sara C et al. (2016) The α-1 adrenoceptor (ADRA1A) genotype moderates the magnitude of acute cocaine-induced subjective effects in cocaine-dependent individuals. Pharmacogenet Genomics 26:428-35
Azadeh, Shabnam; Hobbs, Brian P; Ma, Liangsuo et al. (2016) Integrative Bayesian analysis of neuroimaging-genetic data with application to cocaine dependence. Neuroimage 125:813-24
Li, Xiaofan; Shorter, Daryl; Kosten, Thomas R (2016) Buprenorphine Prescribing: To Expand or Not to Expand. J Psychiatr Pract 22:183-92
Brewer 3rd, Alex J; Nielsen, David A; Spellicy, Catherine J et al. (2015) Genetic variation of the dopamine transporter (DAT1) influences the acute subjective responses to cocaine in volunteers with cocaine use disorders. Pharmacogenet Genomics 25:296-304
Shorter, Daryl; Hsieh, John; Kosten, Thomas R (2015) Pharmacologic management of comorbid post-traumatic stress disorder and addictions. Am J Addict 24:705-12
Ma, Liangsuo; Steinberg, Joel L; Cunningham, Kathryn A et al. (2015) Inhibitory behavioral control: A stochastic dynamic causal modeling study comparing cocaine dependent subjects and controls. Neuroimage Clin 7:837-47
Patriquin, Michelle A; Bauer, Isabelle E; Soares, Jair C et al. (2015) Addiction pharmacogenetics: a systematic review of the genetic variation of the dopaminergic system. Psychiatr Genet 25:181-93
Newton, Thomas F; Haile, Colin N; Mahoney 3rd, James J et al. (2015) Dopamine D3 receptor-preferring agonist enhances the subjective effects of cocaine in humans. Psychiatry Res 230:44-9
Bauer, Isabelle E; Soares, Jair C; Nielsen, David A (2015) The role of opioidergic genes in the treatment outcome of drug addiction pharmacotherapy: A systematic review. Am J Addict 24:15-23

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