NEUROIMAGING(Nl)CORE Given the adverse effects of HIV infection (HIV+) and methamphetamine use (METH+) oh brain structure and function, their combined effects, whether additive or synergistic, would be expected to produce a significant brain disorder. Moreover, as treatment of HIV infection has improved longevity and as the large cohort of METH users age, brain changes related to aging and to the comorbidities of aging are likely to contribute to HIV+ and METH+ related alterations in brain structure and function. In particular, age-related cerebrovascular disease might alter cerebral blood flow, potentiate white matter changes and alter gray matter volume. Aging is also likely to exacerbate changes in brain connectivity expected from white matter changes associated with HIV+ and METH+. Whether the aging contribution to changes of brain structure and function is additive or synergistic to that expected from HIV infection or METH use are unknown. This Core proposes to use translational multi-modal imaging to support investigations into the extent to which aging mediates brain changes associated with HIV infection, methamphetamine dependence and their interaction. To support these investigations the Nl Core Resource Objectives are to: (1) provide TMARC investigators with a core set of human and mouse imaging data;(2) provide specialized imaging protocols and advanced image analysis tools to support new directions in emerging imaging technologies;and (3) train investigators in imaging methods. The Nl Core Scientific Objectives are to: (1) investigate the separate and joint brain abnormalities underlying the neuropsychological and functional disabilities of patients with HIV infection and METH use and their interaction with aging;(2) use multimodal imaging methods to link white matter changes seen in METH use and HIV infection to alterations of functional connections among brain centers;(3) use magnetic resonance imaging protocols comparable to those used in human studies to link human imaging findings to imaging findings in mouse models of HIV infection and methamphetamine use.

Public Health Relevance

To understand the combined effects of METH, HIV, and aging on brain injury, the Nl Core will provide advanced brain imaging methods and imaging analysis tools. Animal models of METH, HIV, and aging will also be imaged to better understand the mechanisms of the associated brain injury and how this injury may be prevented or treated.

National Institute of Health (NIH)
Specialized Center (P50)
Project #
Application #
Study Section
Special Emphasis Panel (ZDA1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California San Diego
La Jolla
United States
Zip Code
Morgan, Erin E; Iudicello, Jennifer E; Cattie, Jordan E et al. (2015) Neurocognitive impairment is associated with lower health literacy among persons living with HIV infection. AIDS Behav 19:166-77
Casaletto, K B; Obermeit, L; Morgan, E E et al. (2015) Depression and executive dysfunction contribute to a metamemory deficit among individuals with methamphetamine use disorders. Addict Behav 40:45-50
Maung, Ricky; Hoefer, Melanie M; Sanchez, Ana B et al. (2014) CCR5 knockout prevents neuronal injury and behavioral impairment induced in a transgenic mouse model by a CXCR4-using HIV-1 glycoprotein 120. J Immunol 193:1895-910
Morgan, Erin E; Doyle, Katie L; Minassian, Arpi et al. (2014) Elevated intraindividual variability in methamphetamine dependence is associated with poorer everyday functioning. Psychiatry Res 220:527-34
Kamat, Rujvi; Brown, Gregory G; Bolden, Khalima et al. (2014) Apathy is associated with white matter abnormalities in anterior, medial brain regions in persons with HIV infection. J Clin Exp Neuropsychol 36:854-66
Montoya, Jessica L; Georges, Shereen; Poquette, Amelia et al. (2014) Refining a personalized mHealth intervention to promote medication adherence among HIV+ methamphetamine users. AIDS Care 26:1477-81
Desplats, Paula; Dumaop, Wilmar; Cronin, Peter et al. (2014) Epigenetic alterations in the brain associated with HIV-1 infection and methamphetamine dependence. PLoS One 9:e102555
Henry, Brook L; Geyer, Mark A; Buell, Mahalah R et al. (2014) Prepulse inhibition in HIV-1 gp120 transgenic mice after withdrawal from chronic methamphetamine. Behav Pharmacol 25:12-22
Tatro, Erick T; Purnajo, Intan; Richman, Douglas D et al. (2014) Antibody response to Achromobacter xylosoxidans during HIV infection is associated with lower CD4 levels and increased lymphocyte activation. Clin Vaccine Immunol 21:46-50
Iudicello, Jennifer E; Morgan, Erin E; Gongvatana, Assawin et al. (2014) Detrimental impact of remote methamphetamine dependence on neurocognitive and everyday functioning in older but not younger HIV+ adults: evidence for a legacy effect? J Neurovirol 20:85-98

Showing the most recent 10 out of 44 publications