The persistence of the HIV epidemic is largely fueled by risky drug practices and sexual behaviors related to METH use, but robust and modifiable neurobehavioral predictors of HIV transmission risk behaviors have yet to be identified. Deficient social cognition, which represents problems with understanding and regulating one's own emotions as well as with placing oneself in another's """"""""shoes"""""""" cognitively and emotionally, may negatively impact the ability to safely navigate HIV risk situations that occur in these highly social contexts, especially when decision-making abilities are impaired, such as in the case of persons with comorbid HIV/METH who are vulnerable to frontal systems injury. Given the negative effects of aging on social cognition, older HIV+ adults who use METH may be particulariy vulnerable. Project 3 aims to utilize a 2x2 factorial design in a cohort of 320 individuals (identical to those in PI) to investigate the separate and combined effects of HIV and METH on social cognition, as well as potential modulation of these effects by age. Among the risk groups, the incremental value of social cognition as a predictor of HIV transmission risk behaviors and social functioning will be investigated. This project also aims to examine the neurobehavioral, neurobiological, neuroimaging, and animal model correlates of human social cognition through synergy with other Cores and Projects. We will also relate our findings to those of a proposed pilot study (Pilot Project D in PAD Core) that tests a mouse model of social cognition. A theory-driven model of social cognition will be comprehensively evaluated through integration of emotional and cognitive components, which will be rigorously measured with multiple indices balanced across laboratory performance-based tests and self-report measures. This novel, inclusive approach will fully characterize social cognition in this cohort, as well as its relation to vital daily functioning outcomes, which will likely fill a critically important missing link in the prediction of HIV risk behaviors, allowing for targeted intervention aimed at HIV transmission reduction.

Public Health Relevance

Risky drug use and sexual behaviors are a driving force in the HIV epidemic and typically occur in social contexts. As such the study of social cognition, which allows an individual to understand the emotional and cognitive aspects of social interactions, may help to reduce the HIV transmission rate by identifying those at risk and informing interventions.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Specialized Center (P50)
Project #
2P50DA026306-06
Application #
8601377
Study Section
Special Emphasis Panel (ZDA1)
Project Start
Project End
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
6
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Jones, Jeb; Hoenigl, Martin; Siegler, Aaron J et al. (2017) Assessing the Performance of 3 Human Immunodeficiency Virus Incidence Risk Scores in a Cohort of Black and White Men Who Have Sex With Men in the South. Sex Transm Dis 44:297-302
Osorio, Georgina; Hoenigl, Martin; Quartarolo, Jennifer et al. (2017) Evaluation of opt-out inpatient HIV screening at an urban teaching hospital. AIDS Care 29:1014-1018
Bischoff-Grethe, Amanda; Connolly, Colm G; Jordan, Stephan J et al. (2017) Altered reward expectancy in individuals with recent methamphetamine dependence. J Psychopharmacol 31:17-30
Paolillo, Emily W; Gongvatana, Assawin; Umlauf, Anya et al. (2017) At-Risk Alcohol Use is Associated with Antiretroviral Treatment Nonadherence Among Adults Living with HIV/AIDS. Alcohol Clin Exp Res 41:1518-1525
Hoenigl, Martin; Braun, Dominique L; Kouyos, Roger et al. (2017) Evaluation of the Predictive Potential of the Short Acute Retroviral Syndrome Severity Score for HIV-1 Disease Progression in Individuals With Acute HIV Infection. J Acquir Immune Defic Syndr 74:e114-e117
Woods, Steven Paul; Iudicello, Jennifer E; Morgan, Erin E et al. (2017) Household Everyday Functioning in the Internet Age: Online Shopping and Banking Skills Are Affected in HIV-Associated Neurocognitive Disorders. J Int Neuropsychol Soc 23:605-615
Bortell, Nikki; Basova, Liana; Semenova, Svetlana et al. (2017) Astrocyte-specific overexpressed gene signatures in response to methamphetamine exposure in vitro. J Neuroinflammation 14:49
Kesby, James P; Najera, Julia A; Romoli, Benedetto et al. (2017) HIV-1 TAT protein enhances sensitization to methamphetamine by affecting dopaminergic function. Brain Behav Immun 65:210-221
Sanchez, Ana B; Kaul, Marcus (2017) Neuronal Stress and Injury Caused by HIV-1, cART and Drug Abuse: Converging Contributions to HAND. Brain Sci 7:
Obermeit, Lisa C; Beltran, Jessica; Casaletto, Kaitlin B et al. (2017) Evaluating the accuracy of self-report for the diagnosis of HIV-associated neurocognitive disorder (HAND): defining ""symptomatic"" versus ""asymptomatic"" HAND. J Neurovirol 23:67-78

Showing the most recent 10 out of 129 publications