The persistence of the HIV epidemic is largely fueled by risky drug practices and sexual behaviors related to METH use, but robust and modifiable neurobehavioral predictors of HIV transmission risk behaviors have yet to be identified. Deficient social cognition, which represents problems with understanding and regulating one's own emotions as well as with placing oneself in another's """"""""shoes"""""""" cognitively and emotionally, may negatively impact the ability to safely navigate HIV risk situations that occur in these highly social contexts, especially when decision-making abilities are impaired, such as in the case of persons with comorbid HIV/METH who are vulnerable to frontal systems injury. Given the negative effects of aging on social cognition, older HIV+ adults who use METH may be particulariy vulnerable. Project 3 aims to utilize a 2x2 factorial design in a cohort of 320 individuals (identical to those in PI) to investigate the separate and combined effects of HIV and METH on social cognition, as well as potential modulation of these effects by age. Among the risk groups, the incremental value of social cognition as a predictor of HIV transmission risk behaviors and social functioning will be investigated. This project also aims to examine the neurobehavioral, neurobiological, neuroimaging, and animal model correlates of human social cognition through synergy with other Cores and Projects. We will also relate our findings to those of a proposed pilot study (Pilot Project D in PAD Core) that tests a mouse model of social cognition. A theory-driven model of social cognition will be comprehensively evaluated through integration of emotional and cognitive components, which will be rigorously measured with multiple indices balanced across laboratory performance-based tests and self-report measures. This novel, inclusive approach will fully characterize social cognition in this cohort, as well as its relation to vital daily functioning outcomes, which will likely fill a critically important missing link in the prediction of HIV risk behaviors, allowing for targeted intervention aimed at HIV transmission reduction.

Public Health Relevance

Risky drug use and sexual behaviors are a driving force in the HIV epidemic and typically occur in social contexts. As such the study of social cognition, which allows an individual to understand the emotional and cognitive aspects of social interactions, may help to reduce the HIV transmission rate by identifying those at risk and informing interventions.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Specialized Center (P50)
Project #
2P50DA026306-06
Application #
8601377
Study Section
Special Emphasis Panel (ZDA1)
Project Start
Project End
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
6
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Kamat, Rujvi; Doyle, Katie L; Iudicello, Jennifer E et al. (2016) Neurobehavioral Disturbances During Acute and Early HIV Infection. Cogn Behav Neurol 29:1-10
Noel, Richard J; Kaul, Marcus (2016) The 22nd Scientific Conference of the Society on Neuroimmune Pharmacology. J Neuroimmune Pharmacol 11 Suppl 1:S1-2
Soontornniyomkij, Virawudh; Umlauf, Anya; Soontornniyomkij, Benchawanna et al. (2016) Lifetime methamphetamine dependence is associated with cerebral microgliosis in HIV-1-infected adults. J Neurovirol 22:650-660
Gianella, Sara; Letendre, Scott (2016) Cytomegalovirus and HIV: A Dangerous Pas de Deux. J Infect Dis 214 Suppl 2:S67-74
Kesby, James P; Markou, Athina; Semenova, Svetlana (2016) The effects of HIV-1 regulatory TAT protein expression on brain reward function, response to psychostimulants and delay-dependent memory in mice. Neuropharmacology 109:205-15
Hoenigl, Martin; Little, Susan J (2016) How can we detect HIV during the acute or primary stage of infection? Expert Rev Mol Diagn 16:1049-1051
Bischoff-Grethe, Amanda; Connolly, Colm G; Jordan, Stephan J et al. (2016) Altered reward expectancy in individuals with recent methamphetamine dependence. J Psychopharmacol :
Brown, Gregory G; Jacobus, Joanna; McKenna, Benjamin (2016) Structural imaging for addiction medicine: From neurostructure to neuroplasticity. Prog Brain Res 224:105-27
Hoenigl, Martin; Chaillon, Antoine; Moore, David J et al. (2016) Clear Links Between Starting Methamphetamine and Increasing Sexual Risk Behavior: A Cohort Study Among Men Who Have Sex With Men. J Acquir Immune Defic Syndr 71:551-7
Pérez-Santiago, Josué; Schrier, Rachel D; de Oliveira, Michelli F et al. (2016) Cell-free mitochondrial DNA in CSF is associated with early viral rebound, inflammation, and severity of neurocognitive deficits in HIV infection. J Neurovirol 22:191-200

Showing the most recent 10 out of 108 publications