The Statistical Analysis Core will provide high quality, integrated collaboration in and support of the proposed Center on the role of sex differences on progesterone and impulsivity in cocaine and nicotine addiction. As a foundation for all three proposed projects, this Core will provide: personnel with the appropriate breadth and depth of expertise;services in study design, study logistics planning, data management, and statistical analysis;training and mentoring;and other resources as needed. Core personnel will actively participate with project teams before study initiation, during study execution, and as part of novel cross-project initiatives that will integrate the projects to provide innovative insight into sex differences, progesterone, impulsivity, and addiction. This Core will in particular interact closely and extensively with the Science and Training Core (Core B) and the Administrative Core (Core A) on scientific and management oversight of each project as it is carried out, on the prioritization of SAC work across the needs of the projects, on the ongoing training and mentoring of junior investigators and trainees, and on supporting future research and funding opportunities on sex differences in addiction which are motivated by this proposed Center. Our continuity of involvement, from initial study planning through study completion and into dissemination, will provide a common connection among the projects spanning the entire proposed period. Lastly, we will provide resources for additional exploratory analyses that come to light as the research progresses, taking full advantage of the Center's careful data collection and management, thereby also facilitating the development of innovative hypotheses for future research.

Public Health Relevance

Despite much effort, there are not yet highly effective approved medications for the direct treatment of cocaine and nicotine dependence. This SCOR will carry out interdisciplinary and translational investigations to identify pharmacological interventions targeting behaviors impaired in nicotine and cocaine dependent subjects to enhance the effectiveness of existing behavioral treatments for addiction.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Specialized Center (P50)
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Special Emphasis Panel (ZRG1-EMNR-Q)
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University of Minnesota Twin Cities
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Carroll, Marilyn E; Lynch, Wendy J (2016) How to study sex differences in addiction using animal models. Addict Biol 21:1007-29
Swalve, Natashia; Smethells, John R; Carroll, Marilyn E (2016) Sex differences in the acquisition and maintenance of cocaine and nicotine self-administration in rats. Psychopharmacology (Berl) 233:1005-13
Swalve, Natashia; Smethells, John R; Carroll, Marilyn E (2016) Sex differences in attenuation of nicotine reinstatement after individual and combined treatments of progesterone and varenicline. Behav Brain Res 308:46-52
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Swalve, Natashia; Smethells, John R; Zlebnik, Natalie E et al. (2016) Sex differences in reinstatement of cocaine-seeking with combination treatments of progesterone and atomoxetine. Pharmacol Biochem Behav 145:17-23
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