Program Director/Principal Investigator (Last, First, Middle): Krishnan-Sarin, Suchitra/O'Malley, Stephanie S. The goal of the Pilot Core is to galvanize research within and outside the Yale Tobacco Center of Regulatory Science (TCORS) and to allow investigators to develop preliminary evidence that would enable submission of highly competitive extramural funding applications. The 4 research components of the Yale TCORS focus on understanding the role of tobacco additives and modified risk tobacco products through behavioral, molecular, pharmacological, epidemiological, and economic sciences that involve humans (in clinical, economic, and epidemiological research) and animals (basic research). Projects funded by the Pilot Core will reflect and complement these goals. The Pilot Core will be responsible for review, funding, and oversight of up to 5 TCORS pilot projects per year that are relevant to the goals of the Yale TCORS of reducing the addiction to tobacco products, to the goals of the other TCORS sites, and to the regulatory needs ofthe FDA. Further, in conjunction with the Laboratory and Administrative Cores, the Pilot Core will facilitate the training of junior investigators in the Education and Training Core by providing them with funds to initiate independent research projects that are relevant to tobacco regulatory science. Researchers involved in this proposed TCORS at Yale University have an established history of conducting programs of multidisciplinary research in tobacco use. From 2000-2011, we led an NIH Transdisciplinary Tobacco Use Research Center (TTURC) focused on tobacco dependence and risk factors for treatment failure in order to ultimately develop new approaches for treatment. As part of this effort we successfully solicited and reviewed pilot projects, and supported funding for 33 pilot projects. Fifty-two publications and 14 NIH funded grants resulted from these pilots. Moreover, the TTURC and its pilot mechanism led to the creation and cohesiveness of the Center for Tobacco Use Research at Yale (CENTURY), a core group of more than 25 faculty members who focus on tobacco research (CENTURY website: and has further stimulated tobacco research and collaborations within and outside the Yale community. Thus, our previous experience demonstrates our ability to successfully accomplish the proposed activities.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Specialized Center (P50)
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Study Section
Special Emphasis Panel (ZRG1-BDCN-Q (40))
Project Start
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Yale University
New Haven
United States
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Krishnan-Sarin, Suchitra; Green, Barry G; Kong, Grace et al. (2017) Studying the interactive effects of menthol and nicotine among youth: An examination using e-cigarettes. Drug Alcohol Depend 180:193-199
Gibson, Laura A; Creamer, MeLisa R; Breland, Alison B et al. (2017) Measuring perceptions related to e-cigarettes: Important principles and next steps to enhance study validity. Addict Behav :
Caceres, Ana I; Liu, Boyi; Jabba, Sairam V et al. (2017) Transient Receptor Potential Cation Channel Subfamily M Member 8 channels mediate the anti-inflammatory effects of eucalyptol. Br J Pharmacol 174:867-879
Baldassarri, Stephen R; Hillmer, Ansel T; Anderson, Jon Mikael et al. (2017) Use of Electronic Cigarettes Leads to Significant Beta2-Nicotinic Acetylcholine Receptor Occupancy: Evidence From a PET Imaging Study. Nicotine Tob Res :
Bold, Krysten W; Kong, Grace; Cavallo, Dana A et al. (2017) E-Cigarette Susceptibility as a Predictor of Youth Initiation of E-Cigarettes. Nicotine Tob Res 20:140-144
Kong, Grace; Unger, Jennifer; Baezconde-Garbanati, Lourdes et al. (2017) The Associations between Yelp Online Reviews and Vape Shops Closing or Remaining Open One Year Later. Tob Prev Cessat 2:
Achanta, Satyanarayana; Jordt, Sven-Eric (2017) TRPA1: Acrolein meets its target. Toxicol Appl Pharmacol 324:45-50
Simon, Patricia; Camenga, Deepa R; Kong, Grace et al. (2017) Youth E-cigarette, Blunt, and Other Tobacco Use Profiles: Does SES Matter? Tob Regul Sci 3:115-127
Kong, Grace; Morean, Meghan E; Cavallo, Dana A et al. (2017) Sources of electronic cigarette acquisition among adolescents in Connecticut. Tob Regul Sci 3:10-16
Bold, Krysten W; Sussman, Steve; O'Malley, Stephanie S et al. (2017) Measuring E-cigarette dependence: Initial guidance. Addict Behav :

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