This application requests continuation of the Iowa Cochlear Implant Clinical Research Center. We are engaged in clinical outcomes research studying the application of cochlear implants (Cl) in children and adults. CIs have been successful in providing speech perception to postlingually deafened adults and prelingually deafened children in quiet. Larger populations of hearing impaired subjects, such as those with high-frequency loss and preserved low frequency might also benefit from electrical speech processing. This application plans to refine the criteria for acoustic + electric hearing, study speech in noise, examine the advantages of binaural implantation in adults and children, examine outcomes when age of implantation is reduced to 7 months, and improve the perception of music with implants. All are important issues confronting researchers and clinicians. The overall goals of the proposed research are 1) To determine the boundaries of selection criteria for the acoustic and electrical speech processing implants, 2) Improve and study the benefits of binaural cochlear implants in adults and children using more realistic soundfield hearing tests, 3) Determine if a less invasive electrode in one ear and standard Cl in the other provides similar outcomes as bilateral standard CIs, 4) Refine and expand the way in which electrophysiological measures of auditory function can be used to understand how the auditory system responds to electrical stimulation, 5) Investigate those factors that influence music perception and enjoyment of Cl recipients, and 6) Describe and explain individual differences in perceptual, linguistic, and social outcomes of individuals receiving cochlear implants in childhood. The proposed application will study 372 previously implanted adults and children, 105 newly recruited postlingually deafened adults, and 70 prelingually and postlingually deafened children. Postlingually deafened adults and children with residual low frequency hearing and reduced speech perception will receive implants designed to preserve residual hearing. Binaural implants will be studied in both adults and children. Five research subprojects, an administrative Core A, and Patient Care, Speech Processing, and Technical Core B will address the above goals. The five research subprojects are highly integrated and depend on data from each other to answer the experimental questions proposed.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Specialized Center (P50)
Project #
5P50DC000242-25
Application #
7860464
Study Section
Special Emphasis Panel (ZDC1-SRB-R (37))
Program Officer
Donahue, Amy
Project Start
1985-09-09
Project End
2012-02-14
Budget Start
2010-06-01
Budget End
2012-02-14
Support Year
25
Fiscal Year
2010
Total Cost
$2,462,578
Indirect Cost
Name
University of Iowa
Department
Otolaryngology
Type
Schools of Medicine
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242
McMurray, Bob; Farris-Trimble, Ashley; Rigler, Hannah (2017) Waiting for lexical access: Cochlear implants or severely degraded input lead listeners to process speech less incrementally. Cognition 169:147-164
Tejani, Viral D; Abbas, Paul J; Brown, Carolyn J (2017) Relationship Between Peripheral and Psychophysical Measures of Amplitude Modulation Detection in Cochlear Implant Users. Ear Hear 38:e268-e284
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Abbas, Paul J; Tejani, Viral D; Scheperle, Rachel A et al. (2017) Using Neural Response Telemetry to Monitor Physiological Responses to Acoustic Stimulation in Hybrid Cochlear Implant Users. Ear Hear 38:409-425
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Sjoberg, Kristin M; Driscoll, Virginia D; Gfeller, Kate et al. (2017) The impact of electric hearing on children's timbre and pitch perception and talker discrimination. Cochlear Implants Int 18:36-48
Samuelson, Larissa K; McMurray, Bob (2017) What does it take to learn a word? Wiley Interdiscip Rev Cogn Sci 8:
Oleson, Jacob J; Cavanaugh, Joseph E; McMurray, Bob et al. (2017) Detecting time-specific differences between temporal nonlinear curves: Analyzing data from the visual world paradigm. Stat Methods Med Res 26:2708-2725
Scheperle, Rachel A; Tejani, Viral D; Omtvedt, Julia K et al. (2017) Delayed changes in auditory status in cochlear implant users with preserved acoustic hearing. Hear Res 350:45-57
Brown, Carolyn J; Jeon, Eun-Kyung; Driscoll, Virginia et al. (2017) Effects of Long-Term Musical Training on Cortical Auditory Evoked Potentials. Ear Hear 38:e74-e84

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