The concept of keeping endodontically treated root fragments within the jaws to maintain bone and support dentures has become widely accepted. These dentures have been called overdentures. The primary disadvantages of the overdenture technique are that the root fragments are susceptible to periodontal disease and caries. Preventive techniques such as the home use of topical fluorides seem to be beneficial. Feagin (1983) has suggested that the mechanism of the action of F- in enamel compared to root surfaces may be different and that the commercially available fluorides may not be appropriate for use on root surfaces as they were developed for use on enamel. Feagin has developed a fluoride gel which contains 20 mM calcium ion, 10 mM phosphate ion and 0.75 mM fluoride which in vitro seems to be more effective on root surfaces. A subsample of 180 overdenture patients who have been in the study for at least one year and have shown a susceptibility to caries will be selected. These 50 patients will be randomly divided into 2 groups, one group will remain on the commercial topical fluoride gel, the other will use the experimental gel. The patients will be examined by an independent examiner every 3 months for the next 3 years. Statistical evaluation will be carried out by analysis of co-variance.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Specialized Center (P50)
Project #
5P50DE007010-03
Application #
3963906
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
1986
Total Cost
Indirect Cost
Name
University of Iowa
Department
Type
DUNS #
041294109
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Levy, S M; Maurice, T J; Jakobsen, J R (1993) Feeding patterns, water sources and fluoride exposures of infants and 1-year-olds. J Am Dent Assoc 124:65-9
Almqvist, H; Wefel, J S; Lagerlof, F (1990) Root hard-tissue demineralization rate measured by 125I absorptiometry: comparison with lesion-depth measurements. J Dent Res 69:1519-21
Bowden, G H; Ekstrand, J; McNaughton, B et al. (1990) Association of selected bacteria with the lesions of root surface caries. Oral Microbiol Immunol 5:346-51
Ekstrand, J; Spak, C J; Vogel, G (1990) Pharmacokinetics of fluoride in man and its clinical relevance. J Dent Res 69 Spec No:550-5;discussion 556-7
Oliveby, A; Twetman, S; Ekstrand, J (1990) Diurnal fluoride concentration in whole saliva in children living in a high- and a low-fluoride area. Caries Res 24:44-7
Levy, S M; Jensen, M E (1990) A clinical evaluation of the restoration of root surface caries. Spec Care Dentist 10:156-60
Ekstrand, J; Spak, C J (1990) Fluoride pharmacokinetics: its implications in the fluoride treatment of osteoporosis. J Bone Miner Res 5 Suppl 1:S53-61
Spak, C J; Sjostedt, S; Eleborg, L et al. (1990) Studies of human gastric mucosa after application of 0.42% fluoride gel. J Dent Res 69:426-9
Oliveby, A; Lagerlof, F; Ekstrand, J et al. (1989) Studies on fluoride excretion in human whole saliva and its relation to flow rate and plasma fluoride levels. Caries Res 23:243-6
Ekstrand, J (1989) Fluoride intake in early infancy. J Nutr 119:1856-60

Showing the most recent 10 out of 23 publications