Abstract

The purpose of this Mouse Core is to provide centralized care, breeding, genotyping and quality control of transgenic and knockout animals for use by investigators in the program project. In addition, the core will generate new transgenic and gene targeted mouse models where needed by program investigators. The core will also provide a mechanism for the distribution of new experimental transgenic and knockout models to either depository (such as the Jackson Laboratory Induced Mutant Resource) or to other investigators at the University of Iowa and outside the institution. The overall Core is directed by Dr. Baoli Yang, who currently serves as Director of the Gene Targeting Core Facility on the campus at the University of Iowa and who, in the last four years, has been served as Animal Core Director of the Comprehensive Oral Health Research Center of Discovery (COHRCD).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Specialized Center (P50)
Project #
5P50DE016215-03
Application #
7267097
Study Section
Special Emphasis Panel (ZDE1)
Project Start
Project End
Budget Start
2006-08-01
Budget End
2007-07-31
Support Year
3
Fiscal Year
2006
Total Cost
$124,884
Indirect Cost

  Institution

Name
University of Iowa
Department
Type
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242

  Publications

Howe, Laurence J; Lee, Myoung Keun; Sharp, Gemma C et al. (2018) Investigating the shared genetics of non-syndromic cleft lip/palate and facial morphology. PLoS Genet 14:e1007501
Bureau, Alexandre; Begum, Ferdouse; Taub, Margaret A et al. (2018) Inferring disease risk genes from sequencing data in multiplex pedigrees through sharing of rare variants. Genet Epidemiol :
Fu, Jack; Beaty, Terri H; Scott, Alan F et al. (2017) Whole exome association of rare deletions in multiplex oral cleft families. Genet Epidemiol 41:61-69
Liu, Dongjing; Wang, Hong; Schwender, Holger et al. (2017) Gene-gene interaction of single nucleotide polymorphisms in 16p13.3 may contribute to the risk of non-syndromic cleft lip with or without cleft palate in Chinese case-parent trios. Am J Med Genet A 173:1489-1494
Wise, Alison S; Shi, Min; Weinberg, Clarice R (2016) Family-Based Multi-SNP X Chromosome Analysis Using Parent Information. Front Genet 7:20
Wise, Alison S; Shi, Min; Weinberg, Clarice R (2015) Learning about the X from our parents. Front Genet 6:15
Li, Qing; Kim, Yoonhee; Suktitipat, Bhoom et al. (2015) Gene-Gene Interaction Among WNT Genes for Oral Cleft in Trios. Genet Epidemiol 39:385-94
Wu, Tao; Schwender, Holger; Ruczinski, Ingo et al. (2014) Evidence of gene-environment interaction for two genes on chromosome 4 and environmental tobacco smoke in controlling the risk of nonsyndromic cleft palate. PLoS One 9:e88088
Garg, Paras; Ludwig, Kerstin U; Böhmer, Anne C et al. (2014) Genome-wide analysis of parent-of-origin effects in non-syndromic orofacial clefts. Eur J Hum Genet 22:822-30
Schmidt, Karen L; Neiswanger, Katherine; Cohn, Ellen et al. (2013) Nasolabial fold discontinuity during speech as a possible extended cleft phenotype. Cleft Palate Craniofac J 50:201-6

Showing the most recent 10 out of 112 publications