Abstract

The overall goal of this Facility Core is to: conduct studies aimed at defining the effects of chronic low-level domoic acid (DA) exposure on neurobehavioral development. The Neurobehavioral Assessment Facility Core will provide services for the Mechanisms of Toxicity Research Project and the Human Exposure Research Project. In particular, the Core will provide services for two activities, one involving prenatal exposure to domoic acid, and the other early postnatal exposure. The Core will provide the capability of evaluating the functional development of the central nervous system, through the use of a Developmental Neurotoxicity Test Battery. This test battery includes measures of motor coordination, reflex responses, nociception, learning and memory, and the appearance of developmental landmarks in mice.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Specialized Center (P50)
Project #
1P50ES012762-01
Application #
6750885
Study Section
Special Emphasis Panel (ZES1-LKB-E (OC))
Project Start
2003-08-30
Project End
2008-07-31
Budget Start
2003-08-30
Budget End
2004-12-31
Support Year
1
Fiscal Year
2004
Total Cost
$29,092
Indirect Cost

  Institution

Name
University of Washington
Department
Type
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Wallace, James C; Youngblood, Jessica E; Port, Jesse A et al. (2018) Variability in metagenomic samples from the Puget Sound: Relationship to temporal and anthropogenic impacts. PLoS One 13:e0192412
Port, Jesse A; Cullen, Alison C; Wallace, James C et al. (2014) Metagenomic frameworks for monitoring antibiotic resistance in aquatic environments. Environ Health Perspect 122:222-8
Hubbard, Katherine A; Olson, Claire H; Armbrust, E Virginia (2014) Molecular characterization of Pseudo-nitzschia community structure and species ecology in a hydrographically complex estuarine system (Puget Sound, Washington, USA). Mar Ecol Prog Ser 507:39-55
Marshall, Katharine T; Morris, Robert M (2013) Isolation of an aerobic sulfur oxidizer from the SUP05/Arctic96BD-19 clade. ISME J 7:452-5
Armstrong, Jenna L; Fenske, Richard A; Yost, Michael G et al. (2013) Comparison of polyurethane foam and XAD-2 sampling matrices to measure airborne organophosphorus pesticides and their oxygen analogs in an agricultural community. Chemosphere 92:451-7
Port, Jesse A; Parker, Micaela S; Kodner, Robin B et al. (2013) Identification of G protein-coupled receptor signaling pathway proteins in marine diatoms using comparative genomics. BMC Genomics 14:503
Giordano, Gennaro; Kavanagh, Terrance J; Faustman, Elaine M et al. (2013) Low-level domoic acid protects mouse cerebellar granule neurons from acute neurotoxicity: role of glutathione. Toxicol Sci 132:399-408
Bender, Sara J; Parker, Micaela S; Armbrust, E Virginia (2012) Coupled effects of light and nitrogen source on the urea cycle and nitrogen metabolism over a diel cycle in the marine diatom Thalassiosira pseudonana. Protist 163:232-51
Port, Jesse A; Wallace, James C; Griffith, William C et al. (2012) Metagenomic profiling of microbial composition and antibiotic resistance determinants in Puget Sound. PLoS One 7:e48000
Tsuchiya, Ami; Duff, Rob; Stern, Alan H et al. (2012) Single blood-Hg samples can result in exposure misclassification: temporal monitoring within the Japanese community (United States). Environ Health 11:37

Showing the most recent 10 out of 44 publications