Excellent organization and communication will be the keys to our success. Both will be the responsibility of the Administrative Core. Core personnel will achieve these goals by:1) maintaining a centralized location for the accumulated grants information and research publications;2) providing efficient dissemination of information to the project and core leaders;3) arranging several key conferences and meetings which will provide oversight and planning of the research activities.

Public Health Relevance

The Administrative Core is necessary to coordinate the activities of the Center.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Specialized Center (P50)
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Special Emphasis Panel (ZGM1-PPBC-5)
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University of Pittsburgh
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An, Gary; Kulkarni, Swati (2015) An agent-based modeling framework linking inflammation and cancer using evolutionary principles: description of a generative hierarchy for the hallmarks of cancer and developing a bridge between mechanism and epidemiological data. Math Biosci 260:16-24
Mathew, Shibin; Bartels, John; Banerjee, Ipsita et al. (2014) Global sensitivity analysis of a mathematical model of acute inflammation identifies nonlinear dependence of cumulative tissue damage on host interleukin-6 responses. J Theor Biol 358:132-48
Good, Misty; Sodhi, Chhinder P; Hackam, David J (2014) Evidence-based feeding strategies before and after the development of necrotizing enterocolitis. Expert Rev Clin Immunol 10:875-84
Aerts, Jean-Marie; Haddad, Wassim M; An, Gary et al. (2014) From data patterns to mechanistic models in acute critical illness. J Crit Care 29:604-10
Lu, Peng; Sodhi, Chhinder P; Hackam, David J (2014) Toll-like receptor regulation of intestinal development and inflammation in the pathogenesis of necrotizing enterocolitis. Pathophysiology 21:81-93
Lu, Peng; Sodhi, Chhinder P; Jia, Hongpeng et al. (2014) Animal models of gastrointestinal and liver diseases. Animal models of necrotizing enterocolitis: pathophysiology, translational relevance, and challenges. Am J Physiol Gastrointest Liver Physiol 306:G917-28
Zaaqoq, Akram M; Namas, Rami; Almahmoud, Khalid et al. (2014) Inducible protein-10, a potential driver of neurally controlled interleukin-10 and morbidity in human blunt trauma. Crit Care Med 42:1487-97
Peer, Xavier; An, Gary (2014) Agent-based model of fecal microbial transplant effect on bile acid metabolism on suppressing Clostridium difficile infection: an example of agent-based modeling of intestinal bacterial infection. J Pharmacokinet Pharmacodyn 41:493-507
Emr, Bryanna; Sadowsky, David; Azhar, Nabil et al. (2014) Removal of inflammatory ascites is associated with dynamic modification of local and systemic inflammation along with prevention of acute lung injury: in vivo and in silico studies. Shock 41:317-23
Zhang, Yong; Zhang, Jinxiang; Korff, Sebastian et al. (2014) Delayed neutralization of interleukin 6 reduces organ injury, selectively suppresses inflammatory mediator, and partially normalizes immune dysfunction following trauma and hemorrhagic shock. Shock 42:218-27

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