ECC Unit 4 Computational Unit Investigators: Eric Sobie, Larry Sirovich and David McQueen The computational unit will be located at Mount Sinai. The goals of the Computational Unit (CU) are to provide the computational resources for the computational activities of the Center. These include hardware (see below for current configuration), software (see list of available computational packages), development and maintenance of databases as well as construction of cellular models and their export in XML and SBML to other computers. The unit will support the computational needs of the four research projects as well as the projects related to various training programs described in the EOC. This unit will maintain a Web site (Bulletin Board) to post SBC news, maintain the mailing lists and interface with the STKE site for the public access to the SigPath as well as the educational material. The Unit will have a full time Systems Administrator as well as a programmer to help with the routine programming needs. General Description: The CU will utilize the developing computational facilities that are being built for the SBC. This has been done through an equipment grant from NYSTAR, a New York state agency through an Advanced Research Center grant for which Ravi lyengar was the PI. The major computational resource is a cluster of computers for the use of SBC investigators. It provides the infrastructure for high throughput computing, communications, bioinformatics, databases, and is integrated fully with the institutional resources such as e-mail systems and high-capacity fast connections through lnternet-2. All of the institutions in the SBC are connected through lnternet-2 for educational institutions.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center (P50)
Project #
5P50GM071558-03
Application #
7924849
Study Section
Special Emphasis Panel (ZGM1)
Project Start
Project End
Budget Start
2009-09-01
Budget End
2010-08-31
Support Year
3
Fiscal Year
2009
Total Cost
$133,882
Indirect Cost
Name
Icahn School of Medicine at Mount Sinai
Department
Type
DUNS #
078861598
City
New York
State
NY
Country
United States
Zip Code
10029
Jones, DeAnalisa C; Gong, Jingqi Q X; Sobie, Eric A (2018) A privileged role for neuronal Na+ channels in regulating ventricular [Ca2+] and arrhythmias. J Gen Physiol 150:901-905
Barrette, Anne Marie; Bouhaddou, Mehdi; Birtwistle, Marc R (2018) Integrating Transcriptomic Data with Mechanistic Systems Pharmacology Models for Virtual Drug Combination Trials. ACS Chem Neurosci 9:118-129
Xiong, Yuguang; Soumillon, Magali; Wu, Jie et al. (2017) A Comparison of mRNA Sequencing with Random Primed and 3'-Directed Libraries. Sci Rep 7:14626
Falkenberg, Cibele V; Azeloglu, Evren U; Stothers, Mark et al. (2017) Fragility of foot process morphology in kidney podocytes arises from chaotic spatial propagation of cytoskeletal instability. PLoS Comput Biol 13:e1005433
Gong, Jingqi Q X; Shim, Jaehee V; Núñez-Acosta, Elisa et al. (2017) I love it when a plan comes together: Insight gained through convergence of competing mathematical models. J Mol Cell Cardiol 102:31-33
Hansen, Jens; Meretzky, David; Woldesenbet, Simeneh et al. (2017) A flexible ontology for inference of emergent whole cell function from relationships between subcellular processes. Sci Rep 7:17689
Stern, Alan D; Rahman, Adeeb H; Birtwistle, Marc R (2017) Cell size assays for mass cytometry. Cytometry A 91:14-24
Stillitano, Francesca; Hansen, Jens; Kong, Chi-Wing et al. (2017) Modeling susceptibility to drug-induced long QT with a panel of subject-specific induced pluripotent stem cells. Elife 6:
Ron, Amit; Azeloglu, Evren U; Calizo, Rhodora C et al. (2017) Cell shape information is transduced through tension-independent mechanisms. Nat Commun 8:2145
Flamini, Vittoria; DeAnda, Abe; Griffith, Boyce E (2016) Immersed boundary-finite element model of fluid-structure interaction in the aortic root. Theor Comput Fluid Dyn 30:139-164

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