Project B: Systems Genetics of Meiotic Recombination;Petko Petkov, Kenneth Paigen (Jackson), Karl Broman (U Wisconsin-Madison) Meiotic recombination is a fundamental biological process required by all sexually reproducing organisms. The placement of recombination events determines inheritance of allelic combinations which is of importance in population genetics and evolution. In our previous work we have identified recombination hotspots whose pattern of activity requires combined action of epistatic regulators. The goal of this project is to identify epistatic genes that interact in networks to control the location and activity of recombination hotspots.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center (P50)
Project #
5P50GM076468-08
Application #
8531981
Study Section
Special Emphasis Panel (ZGM1-CBCB-2)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
8
Fiscal Year
2013
Total Cost
$309,789
Indirect Cost
$116,526
Name
Jackson Laboratory
Department
Type
DUNS #
042140483
City
Bar Harbor
State
ME
Country
United States
Zip Code
04609
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Walker, Michael; Billings, Timothy; Baker, Christopher L et al. (2015) Affinity-seq detects genome-wide PRDM9 binding sites and reveals the impact of prior chromatin modifications on mammalian recombination hotspot usage. Epigenetics Chromatin 8:31
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