Project G: Using Multiple Phenotypes to Model Genetic Epistasis;Gregory W. Carter (Jackson) Systems Genetics seeks to infer polygenic regulatory models of complex traits by identifying key genes and mapping networks that give rise to epistasis and plelotropy. The simultaneous modeling of multiple related phenotypes enables greater resolution of the interacting genetic network by providing a large set of constraints on possible solutions. This project will develop methods to exploit multidimensional phenotype data in genetic modeling of disease.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center (P50)
Project #
5P50GM076468-08
Application #
8531967
Study Section
Special Emphasis Panel (ZGM1-CBCB-2)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
8
Fiscal Year
2013
Total Cost
$42,227
Indirect Cost
$18,608
Name
Jackson Laboratory
Department
Type
DUNS #
042140483
City
Bar Harbor
State
ME
Country
United States
Zip Code
04609
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Huang, Yuan; Caputo, Christina R; Noordmans, Gerda A et al. (2014) Identification of novel genes associated with renal tertiary lymphoid organ formation in aging mice. PLoS One 9:e91850
Philip, Vivek M; Tyler, Anna L; Carter, Gregory W (2014) Dissection of complex gene expression using the combined analysis of pleiotropy and epistasis. Pac Symp Biocomput :200-11
Noordmans, Gerda A; Huang, Yuan; Savage, Holly et al. (2014) Genetic analysis of intracapillary glomerular lipoprotein deposits in aging mice. PLoS One 9:e111308
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