Overview Our Virology Core facility provides access to state of the art techniques for research in molecular virology, and thereby expands the capabilities of other Center members by providing them with access to HIV replication assays, siRNA technology, assays for testing the efficiency and sites of action of potential new inhibitors, etc.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center (P50)
Project #
2P50GM082545-06
Application #
8513495
Study Section
Special Emphasis Panel (ZRG1-AARR-K (50))
Project Start
Project End
Budget Start
2012-09-01
Budget End
2013-07-31
Support Year
6
Fiscal Year
2012
Total Cost
$172,063
Indirect Cost
$52,838
Name
University of Utah
Department
Type
DUNS #
009095365
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112
Wang, Haoqing; Cohen, Alexander A; Galimidi, Rachel P et al. (2016) Cryo-EM structure of a CD4-bound open HIV-1 envelope trimer reveals structural rearrangements of the gp120 V1V2 loop. Proc Natl Acad Sci U S A 113:E7151-E7158
Monroe, Nicole; Hill, Christopher P (2016) Meiotic Clade AAA ATPases: Protein Polymer Disassembly Machines. J Mol Biol 428:1897-911
Imam, Sabrina; Talley, Sarah; Nelson, Rachel S et al. (2016) TRIM5α Degradation via Autophagy Is Not Required for Retroviral Restriction. J Virol 90:3400-10
Grime, John M A; Dama, James F; Ganser-Pornillos, Barbie K et al. (2016) Coarse-grained simulation reveals key features of HIV-1 capsid self-assembly. Nat Commun 7:11568
Chen, Jianbo; Rahman, Sheikh Abdul; Nikolaitchik, Olga A et al. (2016) HIV-1 RNA genome dimerizes on the plasma membrane in the presence of Gag protein. Proc Natl Acad Sci U S A 113:E201-8
Chuong, Edward B; Elde, Nels C; Feschotte, Cédric (2016) Regulatory evolution of innate immunity through co-option of endogenous retroviruses. Science 351:1083-7
Ma, Hanhui; Tu, Li-Chun; Naseri, Ardalan et al. (2016) Multiplexed labeling of genomic loci with dCas9 and engineered sgRNAs using CRISPRainbow. Nat Biotechnol 34:528-30
Iwasa, Janet H (2016) The Scientist as Illustrator. Trends Immunol 37:247-50
Li, Yen-Li; Chandrasekaran, Viswanathan; Carter, Stephen D et al. (2016) Primate TRIM5 proteins form hexagonal nets on HIV-1 capsids. Elife 5:
Coey, Aaron; Larsen, Kevin; Puglisi, Joseph D et al. (2016) Heterogeneous structures formed by conserved RNA sequences within the HIV reverse transcription initiation site. RNA 22:1689-1698

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