The Biochemistry Core provides all essential resources for purification and expression of proteins and nucleic acids, and instrumentation and expertise for quantitative analysis of intermolecular interactions, including protein-protein and protein-RNA interactions. In addition, the Biochemistry Core specializes in structure determination of RNA-protein complexes using X-ray and NMR spectroscopy.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center (P50)
Project #
5P50GM082545-07
Application #
8538433
Study Section
Special Emphasis Panel (ZRG1-AARR-K)
Project Start
Project End
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
7
Fiscal Year
2013
Total Cost
$393,165
Indirect Cost
Name
University of Utah
Department
Type
DUNS #
009095365
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112
Sanchez, Jacint G; Okreglicka, Katarzyna; Chandrasekaran, Viswanathan et al. (2014) The tripartite motif coiled-coil is an elongated antiparallel hairpin dimer. Proc Natl Acad Sci U S A 111:2494-9
Ren, Jihui; Pei-Chen Lin, Coney; Pathak, Manish C et al. (2014) A phosphatidylinositol transfer protein integrates phosphoinositide signaling with lipid droplet metabolism to regulate a developmental program of nutrient stress-induced membrane biogenesis. Mol Biol Cell 25:712-27
Purdy, Michael D; Bennett, Brad C; McIntire, William E et al. (2014) Function and dynamics of macromolecular complexes explored by integrative structural and computational biology. Curr Opin Struct Biol 27:138-48
Kovalskyy, Dmytro B; Ivanov, Dmitri N (2014) Recognition of the HIV capsid by the TRIM5? restriction factor is mediated by a subset of pre-existing conformations of the TRIM5? SPRY domain. Biochemistry 53:1466-76
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Narayan, Kedar; Danielson, Cindy M; Lagarec, Ken et al. (2014) Multi-resolution correlative focused ion beam scanning electron microscopy: applications to cell biology. J Struct Biol 185:278-84
Hulme, Amy E; Hope, Thomas J (2014) The cyclosporin A washout assay to detect HIV-1 uncoating in infected cells. Methods Mol Biol 1087:37-46
Lamorte, Louie; Titolo, Steve; Lemke, Christopher T et al. (2013) Discovery of novel small-molecule HIV-1 replication inhibitors that stabilize capsid complexes. Antimicrob Agents Chemother 57:4622-31
Votteler, Jorg; Sundquist, Wesley I (2013) Virus budding and the ESCRT pathway. Cell Host Microbe 14:232-41

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