A major goal of the San Diego Center for Systems Biology is to substantively contribute to the development of, and shape the practice of Systems Biology at the local, national and international level. The mission of the Dissemination and Research Training Core is ? to broaden the impact of the Center?s advances in addressing conceptual and technological challenges ? to develop to Systems Biology community at local, regional, national and international levels. ? to ensure ongoing training of current leaders in meeting the challenges of Systems Biology, Many of the activities described here build on the experience of running programming for the San Diego Consortium for Systems Biology. The SDCSB (www.sdcsb.org) was established in 2004 by Drs. Kiger and Chanda as a grass-roots collaborative effort between the Division of Biological Sciences at UCSD and The Genomics Institute of the Novartis Research Foundation (GNF), to spark the development of a network to advance Systems Biology in the San Diego scientific community. It has grown to encompass all major research institutes in the San Diego/Torrey Pines area, with significant participation and financial support from the local biotech and pharmaceutical industry. This grass roots initiative has been successful at bringing together local scientists across institutional and disciplinary boundaries to share ideas, expertise and resources around Systems Biology. Specifically SDCSB has hosted 4 annual ?Systems-to-Synthesis? Symposia, and 9 workshops on a variety of topics. Leadership has largely been provided by Drs. Kiger, Chanda and Hoffmann. However, maintaining this level of engagement requires institutional support, particularly organizationally ? financial support can continue come from sponsorship by local Biotech. Subsuming the ?Consortium? into the new ?Center? for Systems Biology is therefore in the broad interest of the area?s Systems community.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Specialized Center (P50)
Project #
Application #
Study Section
Special Emphasis Panel (ZGM1-CBCB-2)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California San Diego
La Jolla
United States
Zip Code
Saito, Rintaro; Rocanin-Arjo, Anaïs; You, Young-Hyun et al. (2016) Systems biology analysis reveals role of MDM2 in diabetic nephropathy. JCI Insight 1:e87877
Din, M Omar; Danino, Tal; Prindle, Arthur et al. (2016) Synchronized cycles of bacterial lysis for in vivo delivery. Nature 536:81-5
Gendron, Joshua M; Webb, Kristofor; Yang, Bing et al. (2016) Using the Ubiquitin-modified Proteome to Monitor Distinct and Spatially Restricted Protein Homeostasis Dysfunction. Mol Cell Proteomics 15:2576-93
Singec, Ilyas; Crain, Andrew M; Hou, Junjie et al. (2016) Quantitative Analysis of Human Pluripotency and Neural Specification by In-Depth (Phospho)Proteomic Profiling. Stem Cell Reports 7:527-42
Srivas, Rohith; Shen, John Paul; Yang, Chih Cheng et al. (2016) A Network of Conserved Synthetic Lethal Interactions for Exploration of Precision Cancer Therapy. Mol Cell 63:514-25
Engin, H Billur; Kreisberg, Jason F; Carter, Hannah (2016) Structure-Based Analysis Reveals Cancer Missense Mutations Target Protein Interaction Interfaces. PLoS One 11:e0152929
Steiner, Paul J; Williams, Ruth J; Hasty, Jeff et al. (2016) Criticality and Adaptivity in Enzymatic Networks. Biophys J 111:1078-87
Harper, J Wade; Bennett, Eric J (2016) Proteome complexity and the forces that drive proteome imbalance. Nature 537:328-38
Didovyk, Andriy; Borek, Bartłomiej; Hasty, Jeff et al. (2016) Orthogonal Modular Gene Repression in Escherichia coli Using Engineered CRISPR/Cas9. ACS Synth Biol 5:81-8
Yu, Michael Ku; Kramer, Michael; Dutkowski, Janusz et al. (2016) Translation of Genotype to Phenotype by a Hierarchy of Cell Subsystems. Cell Syst 2:77-88

Showing the most recent 10 out of 146 publications