Abstract

PROGRAM 2: Oscillatory dynamics: PKA Circadian control as modifiers of mast cell responses. One of the central themes of systems biology is the quantitative analysis of the complex dynamical interactions critical to human health. One important signaling pathway, involving protein kinase A (PKA), mediates the daily changes of light on circadian dynamic control. These oscillations underlie the rhythms in pathologies of cardiovascular disease, cancer, sleep disturbances, depression, and allergic immune responses. In this Program, we will explore the mechanisms of circadian rhythms and dynamic control by PKA and the initiation of allergic immune responses in mammalian mast cells, as well as crosstalk to NFKB mediated inflammation.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center (P50)
Project #
5P50GM085764-05
Application #
8729589
Study Section
Special Emphasis Panel (ZGM1-CBCB-2)
Project Start
Project End
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
5
Fiscal Year
2014
Total Cost
$464,580
Indirect Cost
$164,852

  Institution

Name
University of California San Diego
Department
Type
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093

  Publications

Cooper, Robert; Tsimring, Lev; Hasty, Jeff (2018) Microfluidics-Based Analysis of Contact-dependent Bacterial Interactions. Bio Protoc 8:
Martinez-Corral, Rosa; Liu, Jintao; Süel, Gürol M et al. (2018) Bistable emergence of oscillations in growing Bacillus subtilis biofilms. Proc Natl Acad Sci U S A 115:E8333-E8340
Zhang, Wei; Bojorquez-Gomez, Ana; Velez, Daniel Ortiz et al. (2018) A global transcriptional network connecting noncoding mutations to changes in tumor gene expression. Nat Genet 50:613-620
Dai, Xiongfeng; Zhu, Manlu; Warren, Mya et al. (2018) Slowdown of Translational Elongation in Escherichia coli under Hyperosmotic Stress. MBio 9:
Muse, Evan D; Yu, Shan; Edillor, Chantle R et al. (2018) Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP in macrophages. Proc Natl Acad Sci U S A 115:E4680-E4689
Bui, Nam; Huang, Justin K; Bojorquez-Gomez, Ana et al. (2018) Disruption of NSD1 in Head and Neck Cancer Promotes Favorable Chemotherapeutic Responses Linked to Hypomethylation. Mol Cancer Ther 17:1585-1594
Huang, Justin K; Carlin, Daniel E; Yu, Michael Ku et al. (2018) Systematic Evaluation of Molecular Networks for Discovery of Disease Genes. Cell Syst 6:484-495.e5
Ozturk, Kivilcim; Dow, Michelle; Carlin, Daniel E et al. (2018) The Emerging Potential for Network Analysis to Inform Precision Cancer Medicine. J Mol Biol 430:2875-2899
Yan, Jian; Chen, Shi-An A; Local, Andrea et al. (2018) Histone H3 lysine 4 monomethylation modulates long-range chromatin interactions at enhancers. Cell Res 28:204-220
Antonova-Koch, Yevgeniya; Meister, Stephan; Abraham, Matthew et al. (2018) Open-source discovery of chemical leads for next-generation chemoprotective antimalarials. Science 362:

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