The Biostatistical and Biomechanical Measurements Core (BBMC) will provide biostatistics and biomechanical support to SCOR Projects I, II, and III.
AIM1 is to assist with study design, power analyses and data analysis plans.
AIM 2 is to provide engineering support for experimental, clinical and 3-D imaging measurements.
AIM 3 is to provide support for database management and information exchange across SCOR Projects.
AIM 4 is to conduct high quality statistical analyses across SCOR Projects, and AIM 5 is to provide mentoring and training of young investigators in these methods in conjunction with Core C. Core B will assist with technical aspects of tissue property and quantitative histology measurements in Project 1 (30 cadavers), as well as human subjects measurements (n=60) in Project 1. In Project 11 it will assist with post-natal quantification of pubovisceral muscles and their defects in MR images from up to 88 women. In Project 111 it will assist with measurements of vaginal support using biomechanical instrumentation, standardized 3-D MR images and clinical measurements in up to 100 women. Finally, Core B will continue to foster new academic collaborations and interface with industry partners, developing novel instrumentation and analytical techniques as needed.
The important scientific advances envisioned in this project depend on producing novel data that accurately capture complex physiology. Their appropriate statistical analysis is essential to testing the hypotheses outlined in this proposal. Core B will provide the biomechanical testing and statistical support needed to achieve our goals.
|DeLancey, John O L (2017) ""Mommy, how will the baby get out of your tummy? Will it hurt you?"" Am J Obstet Gynecol 217:110-111|
|Harris, John A; Sammarco, Anne G; Swenson, Carolyn W et al. (2017) Are perioperative bundles associated with reduced postoperative morbidity in women undergoing benign hysterectomy? Retrospective cohort analysis of 16,286 cases in Michigan. Am J Obstet Gynecol 216:502.e1-502.e11|
|Sammarco, Anne G; Nandikanti, Lahari; Kobernik, Emily K et al. (2017) Interactions among pelvic organ protrusion, levator ani descent, and hiatal enlargement in women with and without prolapse. Am J Obstet Gynecol 217:614.e1-614.e7|
|Arenholt, Louise T S; Pedersen, Bodil Ginnerup; Glavind, Karin et al. (2017) Paravaginal defect: anatomy, clinical findings, and imaging. Int Urogynecol J 28:661-673|
|Reiner, Caecilia S; Williamson, Tom; Winklehner, Thomas et al. (2017) The 3D Pelvic Inclination Correction System (PICS): A universally applicable coordinate system for isovolumetric imaging measurements, tested in women with pelvic organ prolapse (POP). Comput Med Imaging Graph 59:28-37|
|Swenson, Carolyn W; Smith, Tovia M; Luo, Jiajia et al. (2017) Intraoperative cervix location and apical support stiffness in women with and without pelvic organ prolapse. Am J Obstet Gynecol 216:155.e1-155.e8|
|Fairchild, Pamela S; Kamdar, Neil S; Rosen, Emily R et al. (2017) Ligament shortening compared to vaginal colpopexy at the time of hysterectomy for pelvic organ prolapse. Int Urogynecol J 28:899-905|
|Zielinski, Ruth; Kane Low, Lisa; Smith, Abigail R et al. (2017) Body after baby: a pilot survey of genital body image and sexual esteem following vaginal birth. Int J Womens Health 9:189-198|
|DeLancey, John O L (2016) What's new in the functional anatomy of pelvic organ prolapse? Curr Opin Obstet Gynecol 28:420-9|
|Berger, Mitchell B; Khandwala, Nikhila; Fenner, Dee E et al. (2016) Colovaginal Fistulas: Presentation, Evaluation, and Management. Female Pelvic Med Reconstr Surg 22:355-8|
Showing the most recent 10 out of 118 publications