The Biostatistical and Biomechanical Measurements Core (BBMC) will provide biostatistics and biomechanical support to SCOR Projects I, II, and III.
AIM1 is to assist with study design, power analyses and data analysis plans.
AIM 2 is to provide engineering support for experimental, clinical and 3-D imaging measurements.
AIM 3 is to provide support for database management and information exchange across SCOR Projects.
AIM 4 is to conduct high quality statistical analyses across SCOR Projects, and AIM 5 is to provide mentoring and training of young investigators in these methods in conjunction with Core C. Core B will assist with technical aspects of tissue property and quantitative histology measurements in Project 1 (30 cadavers), as well as human subjects measurements (n=60) in Project 1. In Project 11 it will assist with post-natal quantification of pubovisceral muscles and their defects in MR images from up to 88 women. In Project 111 it will assist with measurements of vaginal support using biomechanical instrumentation, standardized 3-D MR images and clinical measurements in up to 100 women. Finally, Core B will continue to foster new academic collaborations and interface with industry partners, developing novel instrumentation and analytical techniques as needed.
The important scientific advances envisioned in this project depend on producing novel data that accurately capture complex physiology. Their appropriate statistical analysis is essential to testing the hypotheses outlined in this proposal. Core B will provide the biomechanical testing and statistical support needed to achieve our goals.
|Kim, Jinyong; Betschart, Cornelia; Ramanah, Rajeev et al. (2015) Anatomy of the pubovisceral muscle origin: Macroscopic and microscopic findings within the injury zone. Neurourol Urodyn 34:774-80|
|Suskind, Anne M; Dunn, Rodney L; Morgan, Daniel M et al. (2015) A screening tool for clinically relevant urinary incontinence. Neurourol Urodyn 34:332-5|
|Cameron, Anne P; Suskind, Anne M; Neer, Charlene et al. (2015) Functional and anatomical differences between continent and incontinent men post radical prostatectomy on urodynamics and 3T MRI: a pilot study. Neurourol Urodyn 34:527-32|
|Luo, Jiajia; Smith, Tovia M; Ashton-Miller, James A et al. (2014) In vivo properties of uterine suspensory tissue in pelvic organ prolapse. J Biomech Eng 136:021016|
|Low, Lisa Kane; Zielinski, Ruth; Tao, Yebin et al. (2014) Predicting Birth-Related Levator Ani Tear Severity in Primiparous Women: Evaluating Maternal Recovery from Labor and Delivery (EMRLD Study). Open J Obstet Gynecol 4:266-278|
|Yousuf, Aisha; Chen, Luyun; Larson, Kindra et al. (2014) The length of anterior vaginal wall exposed to external pressure on maximal straining MRI: relationship to urogenital hiatus diameter, and apical and bladder location. Int Urogynecol J 25:1349-56|
|Suskind, Anne M; DeLancey, John O L; Hussain, Hero K et al. (2014) Dynamic MRI evaluation of urethral hypermobility post-radical prostatectomy. Neurourol Urodyn 33:312-5|
|Berger, Mitchell B; Morgan, Daniel M; DeLancey, John O (2014) Levator ani defect scores and pelvic organ prolapse: is there a threshold effect? Int Urogynecol J 25:1375-9|
|Stafford, Ryan E; Mazzone, Stuart; Ashton-Miller, James A et al. (2014) Dynamics of male pelvic floor muscle contraction observed with transperineal ultrasound imaging differ between voluntary and evoked coughs. J Appl Physiol (1985) 116:953-60|
|Betschart, Cornelia; Kim, Jinyong; Miller, Janis M et al. (2014) Comparison of muscle fiber directions between different levator ani muscle subdivisions: in vivo MRI measurements in women. Int Urogynecol J 25:1263-8|
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