The overarching aim of the proposed work is to merge, in our investigation of the genetic bases of SRD, the two prevalent hypotheses used to study genetic foundations of complex common traits/disorders-the common disorder-common variant (CDCV) and the common disorder-rare variant (CDRV) hypotheses. To achieve this merge. Project VI is designed as a two-stage study. The first stage will focus on sequencing DNA from 60 study participants (30 SRD+ and 30 SRD-individuals of African descent). The overarching objective of this effort will be to identify group-specific patterns of variation in the genomic DNA sequence. This identificafion will be carried out by means of whole-genome paired-end sequencing, performed in a staggered fashion, so that informative analyses of multiple freezes are possible. The second stage will verify and clarify the results ofthe first stage. Specifically, the expected result ofthe first-stage analyses will be the identification of groups of candidate genes or candidate funcfional elements for SRD, which will be further investigated in subsequent analyses of large, independent samples of SRD probands and their families (total n~3,000). Through both stages of the investigation, we will attempt to correlate the """"""""genomotype"""""""" of SRD with the SRD diagnosis itself and its componential facets.

Public Health Relevance

This project is designed to contribute to the ongoing investigation of the genetic bases of SRD. It capitalizes on new theoretical and technological developments in the field of genetics and genomics and focuses on a subsample of individuals with SRD currently underrepresented in the field, that is, African-American probands with SRD and their families.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Specialized Center (P50)
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Special Emphasis Panel (ZHD1)
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Florida State University
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Connor, Carol McDonald (2016) A Lattice Model of the Development of Reading Comprehension. Child Dev Perspect 10:269-274
Little, Callie W; Hart, Sara A; Schatschneider, Christopher et al. (2016) Examining Associations Among ADHD, Homework Behavior, and Reading Comprehension: A Twin Study. J Learn Disabil 49:410-23
Spiegel, Jamie A; Lonigan, Christopher J; Phillips, Beth M (2016) Factor Structure and Utility of the Behavior Rating Inventory of Executive Function-Preschool Version. Psychol Assess :
Little, Callie W; Haughbrook, Rasheda; Hart, Sara A (2016) Cross-Study Differences in the Etiology of Reading Comprehension: a Meta-Analytical Review of Twin Studies. Behav Genet :
Little, Callie W; Hart, Sara A; Quinn, Jamie M et al. (2016) Exploring the Co-Development of Reading Fluency and Reading Comprehension: A Twin Study. Child Dev :
Tighe, Elizabeth L; Schatschneider, Christopher (2016) A Quantile Regression Approach to Understanding the Relations Among Morphological Awareness, Vocabulary, and Reading Comprehension in Adult Basic Education Students. J Learn Disabil 49:424-36
Jasińska, Kaja K; Molfese, Peter J; Kornilov, Sergey A et al. (2016) The BDNF Val66Met Polymorphism Influences Reading Ability and Patterns of Neural Activation in Children. PLoS One 11:e0157449
Ciullo, Stephen; Ortiz, Miriam B; Al Otaiba, Stephanie et al. (2016) Advanced Reading Comprehension Expectations in Secondary School: Considerations for Students with Emotional or Behavior Disorders. J Disabil Policy Stud 27:54-64
Tighe, Elizabeth L; Schatschneider, Christopher (2016) Examining the Relationships of Component Reading Skills to Reading Comprehension in Struggling Adult Readers: A Meta-Analysis. J Learn Disabil 49:395-409
Wood, Carla; Appleget, Allyssa; Hart, Sara (2016) Core vocabulary in written personal narratives of school-age children. Augment Altern Commun 32:198-207

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