The UCAMC SCOR Administrative Core has the following major objectives: 1) provide scientific leadership for a focused translational and transdisciplinary research program on the consequences of the loss of gonadal function;2) critically evaluate the progress and productivity of SCOR research projects;3) encourage the generation of new hypotheses related to the thematic focus of the SCOR through an Ancillary Projects program;4) expand the cadre of investigators conducting research on the gonadal regulation of energy balance and metabolism, with an emphasis on junior investigators, through the Ancillary Projects program;5) integrate activities of the SCOR with closely partnered programs at UCAMC, including the Center on Aging, the BIRCWH, the Center for Women's Health Research, the Nutrition and Obesity Research Center, the Women's Reproductive Health Research Career Development program, and the Colorado Clinical and Translational Science Institute;6) provide biostatistical and data management support for the SCOR research projects;and 7) provide administrative support for the financial oversight, regulatory oversight, and scheduling and general management of SCOR activities. The objectives will be carried fonward by a strong team of leaders. Wendy Kohrt, PhD, will be the Core Director and Associate Directors will be Dwight Klemm, PhD, and Paul MacLean, PhD. The Scientific Advisory Committee will be internal and include: Robert Eckel, MD, the Charles A Boettcher II Endowed Chair in Atherosclerosis and Professor of Medicine;Judith Regensteiner, PhD, Professor of Medicine and Director of the CWHR and BIRCWH; Nanette Santoro, MD, Professor and E Stewart Taylor Chair of the Department of Obstetrics and Gynecology and Director of the WHRH;and Robert Schwartz, MD, the Goodstein Professor of Medicine/Geriatrics, Head of Geriatric Medicine, and Director of the Center on Aging. The Ancillary Projects program will invest $50,000 per year to support projects aligned with the thematic focus of the SCOR that are led by teams ofjunior and senior investigators. This will serve to expand the reach of the SCOR and increase the cadre of investigators involved in research on sex differences and women's health.

Public Health Relevance

The Scientific Leaders of the SCOR are outstanding scientists with experience in interdisciplinary research aligned with the thematic focus of the SCOR, are experienced in the successful creation and growth of institutional research centers, serve in key leadership positions that will facilitate the growth and expansion of the SCOR, and are dedicated to advancing research on sex differences and women's health.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Specialized Center (P50)
Project #
5P50HD073063-03
Application #
8719148
Study Section
Special Emphasis Panel (ZRG1-EMNR-Q)
Project Start
Project End
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
3
Fiscal Year
2014
Total Cost
$126,684
Indirect Cost
$43,884
Name
University of Colorado Denver
Department
Type
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045
Gavin, Kathleen M; Kohrt, Wendy M; Klemm, Dwight J et al. (2018) Modulation of Energy Expenditure by Estrogens and Exercise in Women. Exerc Sport Sci Rev 46:232-239
MacLean, Paul S; Rothman, Alexander J; Nicastro, Holly L et al. (2018) The Accumulating Data to Optimally Predict Obesity Treatment (ADOPT) Core Measures Project: Rationale and Approach. Obesity (Silver Spring) 26 Suppl 2:S6-S15
Rynders, Corey A; Schmidt, Stacy L; Bergouignan, Audrey et al. (2018) Effects of short-term sex steroid suppression on dietary fat storage patterns in healthy males. Physiol Rep 6:
Gavin, Kathleen M; Sullivan, Timothy M; Kohrt, Wendy M et al. (2018) Ovarian Hormones Regulate the Production of Adipocytes From Bone Marrow-Derived Cells. Front Endocrinol (Lausanne) 9:276
Hildreth, Kerry L; Ozemek, Cemal; Kohrt, Wendy M et al. (2018) Vascular dysfunction across the stages of the menopausal transition is associated with menopausal symptoms and quality of life. Menopause 25:1011-1019
Lanaspa, Miguel A; Kuwabara, Masanari; Andres-Hernando, Ana et al. (2018) High salt intake causes leptin resistance and obesity in mice by stimulating endogenous fructose production and metabolism. Proc Natl Acad Sci U S A 115:3138-3143
Perreault, Leigh; Newsom, Sean A; Strauss, Allison et al. (2018) Intracellular localization of diacylglycerols and sphingolipids influences insulin sensitivity and mitochondrial function in human skeletal muscle. JCI Insight 3:
Melanson, Edward L; Lyden, Kate; Gibbons, Ellie et al. (2018) Influence of Estradiol Status on Physical Activity in Premenopausal Women. Med Sci Sports Exerc 50:1704-1709
Gavin, Kathleen M; Shea, Karen L; Gibbons, Ellie et al. (2018) Gonadotropin-releasing hormone agonist in premenopausal women does not alter hypothalamic-pituitary-adrenal axis response to corticotropin-releasing hormone. Am J Physiol Endocrinol Metab 315:E316-E325
Foright, R M; Presby, D M; Sherk, V D et al. (2018) Is regular exercise an effective strategy for weight loss maintenance? Physiol Behav 188:86-93

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