The Center for Integration of Research on Genetics and Ethics (CIRGE) was established in 2004. The overall goal of CIRGE is the proactive identification and integration of ethical, legal and social considerations into the design and conduct of current and emerging genetic research. Our thematic focus is on genomics of behavioral traits.
The aims of CIRGE in this renewal application are to: 1) Conduct interdisciplinary ELSI research that informs policy regarding the conduct and translation of research on the genomics of behavior;2) Develop an anticipatory approach to integrate ethics, policy and research on the genomics of behavior by linking the process of research on the genomics of behavior with the ELSI research and policy agendas;and 3) Train interdisciplinary ELSI researchers who are fluent in genomics, ethics and policy. CIRGE will serve as a nexus between stakeholders and end-users of the research on the genomics of behavior, genome scientists, and the ELSI research community. We will create a forum for integrating ethical and social considerations into specific areas of genomic research through: 1) "prognostic" normative analyses that identify the values, principles and assumptions implicated by research, technology and their applications, 2) empirical analyses to map relevant genomic research and technology and identify stakeholders, 3) empirical analyses to assess relevant features of the ethical, legal or social context, such as how different stakeholders think genome information or technology will be used, should be used, is perceived, or who it might benefit or harm, 4) "diagnostic" normative analyses to assess whether and how genomic research and technology supports or undermines stakeholder values, and 5) feedback of normative and empirical ELSI findings into research and development priorities, design criteria or other requirements. These processes can inform the design and application of genome research to enhance benefit and utility to end-users and facilitate translation to clinical and non-medical uses. CIRGE's innovation will be in developing a process for coordinating ELSI research agendas around specific focus areas in genomic research, and for translating the ELSI research findings into design features of genomic research and technology.

Public Health Relevance

CIRGE's aims to facilitate the appropriate and ethical translation of research on the genomics of behavior in a way that serves the needs and values of end users and stakeholders, including patients, clinicians, and health policy makers.

Agency
National Institute of Health (NIH)
Institute
National Human Genome Research Institute (NHGRI)
Type
Specialized Center (P50)
Project #
5P50HG003389-10
Application #
8634809
Study Section
Special Emphasis Panel (ZHG1-HGR-P (J1))
Program Officer
Mcewen, Jean
Project Start
2004-09-01
Project End
2015-02-28
Budget Start
2014-03-01
Budget End
2015-02-28
Support Year
10
Fiscal Year
2014
Total Cost
$1,032,709
Indirect Cost
$386,531
Name
Stanford University
Department
Social Sciences
Type
Schools of Medicine
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94305
Ormond, Kelly E; Cho, Mildred K (2014) Translating personalized medicine using new genetic technologies in clinical practice: the ethical issues. Per Med 11:211-222
Kellogg, Gregory; Slattery, Leah; Hudgins, Louanne et al. (2014) Attitudes of mothers of children with down syndrome towards noninvasive prenatal testing. J Genet Couns 23:805-13
Grove, Megan E; Wolpert, Maya N; Cho, Mildred K et al. (2014) Views of genetics health professionals on the return of genomic results. J Genet Couns 23:531-8
Milner, Lauren C; Cho, Mildred K (2014) Focusing on Cause or Cure?: Priorities and Stakeholder Presence in Childhood Psychiatry Research. AJOB Prim Res 5:44-55
Erickson, Jessica A; Kuzmich, Lili; Ormond, Kelly E et al. (2014) Genetic testing of children for predisposition to mood disorders: anticipating the clinical issues. J Genet Couns 23:566-77
Dewey, Frederick E; Grove, Megan E; Pan, Cuiping et al. (2014) Clinical interpretation and implications of whole-genome sequencing. JAMA 311:1035-45
Daneshjou, Roxana; Zappala, Zachary; Kukurba, Kim et al. (2014) PATH-SCAN: a reporting tool for identifying clinically actionable variants. Pac Symp Biocomput :229-40
Liu, Emily Yang; Scott, Christopher Thomas (2014) Great expectations: autism spectrum disorder and induced pluripotent stem cell technologies. Stem Cell Rev 10:145-50
Allyse, M; Sayres, L C; Goodspeed, T A et al. (2014) Attitudes towards non-invasive prenatal testing for aneuploidy among US adults of reproductive age. J Perinatol 34:429-34
Sayres, Lauren C; Allyse, Megan; Goodspeed, Taylor A et al. (2014) Demographic and experiential correlates of public attitudes towards cell-free fetal DNA screening. J Genet Couns 23:957-67

Showing the most recent 10 out of 51 publications