DNA sequencing is arguably the core technology at the heart of genomics. The idea of having a reference sequence of the human genome grew out of the Sanger-Coulson and Maxam-Gilbert sequencing technologies developed in the 1970s.[62] The history of DNA sequencing is of considerable interest in its own right. That history is also important to understand the academic-industrial-government ecosystem in which genomics takes place, and to inform policy choices about future genomic technologies. This Project will carry forward the work started in CpG 1.0 on DNA sequencing technologies and norms of sharing data that took root in different subfields of genomics. It will then look ahead to full-genome sequence analysis of individuals as it gets faster, cheaper, and more widely used in both clinical medicine and personal genomics. A central question is whether the use of DNA sequencing technology might be constrained by existing DNA patents. This Project will draw on the legal scholarship in Projects 1 and 2 (Rai, Reichman), with implications for Project 6 (Angrist).

Agency
National Institute of Health (NIH)
Institute
National Human Genome Research Institute (NHGRI)
Type
Specialized Center (P50)
Project #
5P50HG003391-08
Application #
8450003
Study Section
Special Emphasis Panel (ZHG1-HGR-P)
Project Start
Project End
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
8
Fiscal Year
2013
Total Cost
$115,891
Indirect Cost
$42,075
Name
Duke University
Department
Type
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Burke, Wylie; Appelbaum, Paul; Dame, Lauren et al. (2015) The translational potential of research on the ethical, legal, and social implications of genomics. Genet Med 17:20-Dec
Angrist, M; Jamal, L (2015) Living laboratory: whole-genome sequencing as a learning healthcare enterprise. Clin Genet 87:311-8
Cook-Deegan, Robert; Chandrasekharan, Subhashini (2014) Patents and genome-wide DNA sequence analysis: is it safe to go into the human genome? J Law Med Ethics 42 Suppl 1:42-50
Angrist, Misha (2014) Open window: when easily identifiable genomes and traits are in the public domain. PLoS One 9:e92060
Chandrasekharan, Subhashini; McGuire, Amy L; Van den Veyver, Ignatia B (2014) Do recent US Supreme Court rulings on patenting of genes and genetic diagnostics affect the practice of genetic screening and diagnosis in prenatal and reproductive care? Prenat Diagn 34:921-6
Chandrasekharan, Subhashini; Minear, Mollie A; Hung, Anthony et al. (2014) Noninvasive prenatal testing goes global. Sci Transl Med 6:231fs15
Cook-Deegan, Robert (2013) Are human genes patentable? Ann Intern Med 159:298-9
Minear, Mollie A; Kapustij, Cristina; Boden, Kaeleen et al. (2013) Cystic Fibrosis Patents: A Case Study of Successful Licensing. LES Nouv :21-30
Mathews, Debra J H; Cook-Deegan, Robert; Bubela, Tania (2013) Patents and misplaced angst: lessons for translational stem cell research from genomics. Cell Stem Cell 12:508-12
Cook-Deegan, Robert; Conley, John M; Evans, James P et al. (2013) The next controversy in genetic testing: clinical data as trade secrets? Eur J Hum Genet 21:585-8

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