Abstract

: The Morphology Core, directed by Dr. Palinski since 1992, is an essential contributor to many of the projects described in all 5 Units. Since its inception in response to the increasing emphasis on the arterial wall, the Morphology Core has assisted investigators of all SCOR units, and has played an essential role in many of our key findings. It provides assistance in tissue preparation, embedding, dissection, histology and immunocytochemistry, autoradiography, in-situ hybridization, light and fluorescence microscopy and microphotography, video-imaging, and sophisticated computer-assisted morphometric analyses.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
2P50HL056989-06
Application #
6577283
Study Section
Project Start
2002-04-01
Project End
2007-03-31
Budget Start
2002-04-01
Budget End
2003-03-31
Support Year
6
Fiscal Year
2002
Total Cost
$112,728
Indirect Cost

  Institution

Name
University of California San Diego
Department
Type
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093

  Publications

Pechlaner, Raimund; Willeit, Peter; Summerer, Monika et al. (2015) Heme oxygenase-1 gene promoter microsatellite polymorphism is associated with progressive atherosclerosis and incident cardiovascular disease. Arterioscler Thromb Vasc Biol 35:229-36
Huang, Wendy; Ghisletti, Serena; Saijo, Kaoru et al. (2011) Coronin 2A mediates actin-dependent de-repression of inflammatory response genes. Nature 470:414-8
Wan, Yihong; Evans, Ronald M (2010) Rosiglitazone activation of PPARgamma suppresses fractalkine signaling. J Mol Endocrinol 44:135-42
Chou, Meng-Yun; Fogelstrand, Linda; Hartvigsen, Karsten et al. (2009) Oxidation-specific epitopes are dominant targets of innate natural antibodies in mice and humans. J Clin Invest 119:1335-49
Bergmark, Claes; Dewan, Asheesh; Orsoni, Alexina et al. (2008) A novel function of lipoprotein [a] as a preferential carrier of oxidized phospholipids in human plasma. J Lipid Res 49:2230-9
Liguori, Antonio; D'Armiento, Francesco P; Palagiano, Antonio et al. (2008) Maternal C-reactive protein and developmental programming of atherosclerosis. Am J Obstet Gynecol 198:281.e1-5
Tsimikas, Sotirios; Aikawa, Masanori; Miller Jr, Francis J et al. (2007) Increased plasma oxidized phospholipid:apolipoprotein B-100 ratio with concomitant depletion of oxidized phospholipids from atherosclerotic lesions after dietary lipid-lowering: a potential biomarker of early atherosclerosis regression. Arterioscler Thromb Vasc Biol 27:175-81
Ricote, Mercedes; Glass, Christopher K (2007) PPARs and molecular mechanisms of transrepression. Biochim Biophys Acta 1771:926-35
Tsimikas, Sotirios; Brilakis, Emmanouil S; Lennon, Ryan J et al. (2007) Relationship of IgG and IgM autoantibodies to oxidized low density lipoprotein with coronary artery disease and cardiovascular events. J Lipid Res 48:425-33
Palinski, Wulf; Yamashita, Tomoya; Freigang, Stefan et al. (2007) Developmental programming: maternal hypercholesterolemia and immunity influence susceptibility to atherosclerosis. Nutr Rev 65:S182-7

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