Core F - Administration (also referred to as the """"""""Administrative Core"""""""") will support the organizational structure of the SCCOR. It will provide the administrative mechanisms for implementing the policy decisions made by the SCCOR leadership to foster interactions between investigators, accelerate the pace of research, coordinate the projects and cores, and insure a productive research effort. The Administrative Core will be directed by the Principal Investigator of the SCCOR, Dr. Ronald Crystal, in order to ensure quality control, to effectively administer both clinical and basic research, to integrate all component Projects and Cores of the SCCOR, and to establish, maintain, and utilize links with existing resources external to the SCCOR such as the Weill Cornell General Clinical Research Center (5 M01 RR00047-45) and the Weill Cornell Curriculum Development Award (1 K30 HL078583-01). The Administrative Core will also be responsible for SCCOR coordination activities to enhance opportunities for collaboration and communication among participating SCCOR centers. The Administrative Core has in place substantial resources which provide a broad and deep ongoing foundation. The Department of Genetic Medicine, which is chaired by Dr. Crystal, will provide the Administrative Core a total of 1,053 square feet of administrative space to support SCCOR activities. The Administrative Core will organize and staff a total of 16 meetings per year re the SCCOR: 12 meetings of the SCCOR Management Committee and 4 meetings of the SCCOR Executive Committee, 2 of which will include the Internal Advisory Committee, and one of which will include the External Advisory Committee. The Administrative Core will be responsible for financial management: allocations of all personnel percent effort on a monthly basis, and ordering of all supplies and consumable reagents for the Projects and Cores. The Administrative Core will prepare manuscripts for publication and will help prepare presentations at relevant meetings. The Director and Associate Director have substantial prior experience at organizing and directing multi-project clinical, translational, and basic research initiatives which are subject to initial and ongoing peer review.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Specialized Center (P50)
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Special Emphasis Panel (ZHL1)
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Weill Medical College of Cornell University
New York
United States
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Strulovici-Barel, Yael; Staudt, Michelle R; Krause, Anja et al. (2016) Persistence of circulating endothelial microparticles in COPD despite smoking cessation. Thorax 71:1137-1144
Barjaktarevic, Igor Z; Crystal, Ronald G; Kaner, Robert J (2016) The Role of Interleukin-23 in the Early Development of Emphysema in HIV1(+) Smokers. J Immunol Res 2016:3463104
Harvey, Ben-Gary; Strulovici-Barel, Yael; Kaner, Robert J et al. (2015) Risk of COPD with obstruction in active smokers with normal spirometry and reduced diffusion capacity. Eur Respir J 46:1589-1597
Gomi, Kazunori; Arbelaez, Vanessa; Crystal, Ronald G et al. (2015) Activation of NOTCH1 or NOTCH3 signaling skews human airway basal cell differentiation toward a secretory pathway. PLoS One 10:e0116507
Wang, Guoqing; Wang, Rui; Strulovici-Barel, Yael et al. (2015) Persistence of smoking-induced dysregulation of miRNA expression in the small airway epithelium despite smoking cessation. PLoS One 10:e0120824
Walters, Matthew S; De, Bishnu P; Salit, Jacqueline et al. (2014) Smoking accelerates aging of the small airway epithelium. Respir Res 15:94
Hessel, Justina; Heldrich, Jonna; Fuller, Jennifer et al. (2014) Intraflagellar transport gene expression associated with short cilia in smoking and COPD. PLoS One 9:e85453
Shaykhiev, Renat; Crystal, Ronald G (2014) Early events in the pathogenesis of chronic obstructive pulmonary disease. Smoking-induced reprogramming of airway epithelial basal progenitor cells. Ann Am Thorac Soc 11 Suppl 5:S252-8
Brekman, Angelika; Walters, Matthew S; Tilley, Ann E et al. (2014) FOXJ1 prevents cilia growth inhibition by cigarette smoke in human airway epithelium in vitro. Am J Respir Cell Mol Biol 51:688-700
Gao, Chuan; Tignor, Nicole L; Salit, Jacqueline et al. (2014) HEFT: eQTL analysis of many thousands of expressed genes while simultaneously controlling for hidden factors. Bioinformatics 30:369-76

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