The Latino health paradox intrigues researchers because it seems too good to be true: Better health outcomes for individuals with fewer resources. Why does acculturation to norms in the US, despite being accompanied by increased access to health resources and income, seem to contribute to worse health outcomes? To date, the study of acculturation and health risk has focused on behavioral factors, rather than on physiological phenotypes. There is an urgent public health need to gain insight into the cardiovascular health of Latinos, especially Mexican-Americans, an ethnic group increasingly prone to obesity-related comorbidities but understudied for cardiovascular risk factors. This interdisciplinary project will determine cardiovascular function in younger and older related adults varying in generational and immigrant status to increase understanding of the basis for the Latino acculturation paradox. 200 subjects from 100 families in East Los Angeles, including one family member from both an older and a younger generation will be enrolled. The project aims are to 1) Evaluate cardiovascular phenotypes, including arterial stiffness, endothelial function, cardiovascular risk factors and metabolic syndrome in Latino families;and 2) Evaluate the extent to which the Latino paradox holds within these families, based on their generational status and level of acculturation. Measurements will be determined at baseline and after 24 months follow-up. The primary outcome is arterial stiffness measured by applanation tonometry. Secondary outcomes include endothelial function via brachial artery flow-mediated dilation, cardiorespiratory fitness via incremental exercise test, and cardiovascular disease risk biomarkers including markers of endothelial dysfunction (soluble intracellular adhesion molecule-1 and E-selectin), oxidative stress (oxidized LDL and myeloperoxidase), systemic inflammation (C-reactive protein), and fibrinolysis. Other outcomes required to test the hypotheses include components of metabolic syndrome, diet, physical activity level and measures of acculturation. If our hypotheses are supported, more importance may be placed on taking acculturation into account when designing lifestyle change interventions designed to improve Latino cardiovascular health.

Public Health Relevance

Latinos are especially prone to future obesity-related co-morbidities related to the metabolic syndrome and cardiovascular disease. This study evaluates cardiovascular health in Latinos using non-invasive, yet sensitive methodologies, with the goal of increasing knowledge about major social influences on a variety of measures of Latino cardiovascular health and improving understanding of the Latino acculturation paradox.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
5P50HL105188-05
Application #
8604732
Study Section
Special Emphasis Panel (ZCA1-SRLB-3)
Project Start
Project End
Budget Start
2014-01-01
Budget End
2014-12-31
Support Year
5
Fiscal Year
2014
Total Cost
$266,934
Indirect Cost
$77,865
Name
University of California Los Angeles
Department
Type
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Alcalá, Héctor E; Albert, Stephanie L; Trabanino, Shawn K et al. (2016) Access to and Use of Health Care Services Among Latinos in East Los Angeles and Boyle Heights. Fam Community Health 39:62-71
Hohl, Sarah D; Thompson, Beti; Krok-Schoen, Jessica L et al. (2016) Characterizing Community Health Workers on Research Teams: Results From the Centers for Population Health and Health Disparities. Am J Public Health 106:664-70
Langellier, Brent A; Chen, Jie; Vargas-Bustamante, Arturo et al. (2016) Understanding health-care access and utilization disparities among Latino children in the United States. J Child Health Care 20:133-44
Chen, Jie; Vargas-Bustamante, Arturo; Mortensen, Karoline et al. (2016) Racial and Ethnic Disparities in Health Care Access and Utilization Under the Affordable Care Act. Med Care 54:140-6
Alcalá, Héctor E; Albert, Stephanie L; Ortega, Alexander N (2016) E-cigarette use and disparities by race, citizenship status and language among adolescents. Addict Behav 57:30-4
Gill, Monique; Chan-Golston, Alec M; Rice, Lindsay N et al. (2016) Consistency of Moderate to Vigorous Physical Activity in Middle School Physical Education. Fam Community Health 39:283-92
Ortega, Alexander N; Albert, Stephanie L; Chan-Golston, Alec M et al. (2016) Substantial improvements not seen in health behaviors following corner store conversions in two Latino food swamps. BMC Public Health 16:389
Alcalá, Héctor E; Sharif, Mienah Z; Albert, Stephanie L (2016) Social cohesion and the smoking behaviors of adults living with children. Addict Behav 53:201-5
Cavallo, David N; Horino, Masako; McCarthy, William J (2016) Adult Intake of Minimally Processed Fruits and Vegetables: Associations with Cardiometabolic Disease Risk Factors. J Acad Nutr Diet 116:1387-94
Smith, Caren E; Fullerton, Stephanie M; Dookeran, Keith A et al. (2016) Using Genetic Technologies To Reduce, Rather Than Widen, Health Disparities. Health Aff (Millwood) 35:1367-73

Showing the most recent 10 out of 49 publications