This project is designed to extend our understanding of glutamatergic function in schizophrenia by applying proton magnetic resonance spectroscopy (1H MRS) and functional magnetic resonance imaging (fMRI) methods. Specifically, we propose to assess superior temporal and dorsolateral prefrontal cortical (DLPFC) concentrations of N-acetyl-L- aspartate (NAA) using 1H MRS, as well as cortical activation during verbal fluency tasks before and after 8 weeks of treatment with D- cycloserine (DCS), partial NMDA receptor agonist, using fMRI. In addition, methods for the MRS detection and quantification of N-acetyl- aspartyl-glutamate (NAAG) will be developed and implemented using a new 4 Tesla MR scanner.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center (P50)
Project #
1P50MH060450-01A1
Application #
6405546
Study Section
Special Emphasis Panel (ZMH1)
Project Start
2000-07-21
Project End
2005-06-30
Budget Start
Budget End
Support Year
1
Fiscal Year
2000
Total Cost
Indirect Cost
Name
Harvard University
Department
Type
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115
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