The Clinical Evaluation Core's goals are to: (1) recruit, characterize, and follow all human subjects participating in projects #2-7 of the CCNMD (2) develop and maintain state-of-the-art methods for clinical characterization of human framework for testing the stress-diathesis model of suicidal behavior. The CEC identified and recruits patients with MDE, BPD, and Schizophrenia across the life cycle (and post-mortem). Normal volunteers are recruited to provide normative values on the clinical and neurobiological measures used and to establish psychometric properties of measures in a non-pathological population. The CEC utilizes a core of clinical/neuropsychological instruments covering major risk factor domains for suicidal behavior, and ensures uniformity of assessment domains and measures across the projects of the CCNMD. These assessments include Axis I and II diagnostic interviews, measures of state and trait-related risk factors, neuropsychological assessment, measures of suicidal behavior, demographic history, life events, social functioning, family psychiatric history. Assessments are performed at intake, at time of biological procedures, at discharge, at 3 month, 1 and 2 year follow-up. The CEC investigates, develops and tests new assessment procedures to address current and future needs in the field of suicide research, and regularly reviews the reliability and validity of instruments. The CEC ensures the quality of clinical assessments through inter-rater reliability rounds using live or taped interviews. On all measures, our faculty provides consultation to investigators in research methodology and result interpretation. The CEC faculty provides consultation to investigators in research methodology and result interpretation. The CEC has successfully recruited and followed adequate members of life subjects in the proposed diagnostic and age categories. The training and reliability of all CCNMD raters is coordinated by the CEC. The CEC works with SCC staff in developing forms, data management procedures and in generating reliability statistics The CEC coordinates with the BIC regarding recruitment, interviewing, control matching and subject flow. The CEC obtains the blood and cerebrospinal fluid from subjects to be analyzed by the CLC. The CEC interfaces with the Administrative Core regarding recruitment of new staff and maintenance of a central database of all CEC manuscripts. The CEC coordinates all diagnostic consensus conferences.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center (P50)
Project #
5P50MH062185-02
Application #
6480789
Study Section
Special Emphasis Panel (ZMH1)
Project Start
2001-07-01
Project End
2002-06-30
Budget Start
Budget End
Support Year
2
Fiscal Year
2001
Total Cost
$177,169
Indirect Cost
Name
New York State Psychiatric Institute
Department
Type
DUNS #
167204994
City
New York
State
NY
Country
United States
Zip Code
10032
Kaufman, Joshua; DeLorenzo, Christine; Choudhury, Sunia et al. (2016) The 5-HT1A receptor in Major Depressive Disorder. Eur Neuropsychopharmacol 26:397-410
Yin, Honglei; Pantazatos, Spiro P; Galfalvy, Hanga et al. (2016) A pilot integrative genomics study of GABA and glutamate neurotransmitter systems in suicide, suicidal behavior, and major depressive disorder. Am J Med Genet B Neuropsychiatr Genet 171B:414-26
Yin, Honglei; Galfalvy, Hanga; Pantazatos, Spiro P et al. (2016) GLUCOCORTICOID RECEPTOR-RELATED GENES: GENOTYPE AND BRAIN GENE EXPRESSION RELATIONSHIPS TO SUICIDE AND MAJOR DEPRESSIVE DISORDER. Depress Anxiety 33:531-40
Strupp-Levitsky, Michael; Miller, Jeffrey M; Rubin-Falcone, Harry et al. (2016) Lack of association between the serotonin transporter and serotonin 1A receptor: an in vivo PET imaging study in healthy adults. Psychiatry Res 255:81-6
Barakauskas, Vilte E; Moradian, Annie; Barr, Alasdair M et al. (2016) Quantitative mass spectrometry reveals changes in SNAP-25 isoforms in schizophrenia. Schizophr Res 177:44-51
Sublette, M Elizabeth; Vaquero, Concepcion; Baca-Garcia, Enrique et al. (2016) Lack of association of SNPs from the FADS1-FADS2 gene cluster with major depression or suicidal behavior. Psychiatr Genet 26:81-6
Kumar, J S Dileep; Underwood, Mark D; Simpson, Norman R et al. (2016) Autoradiographic Evaluation of [(18)F]FECUMI-101, a High Affinity 5-HT1AR Ligand in Human Brain. ACS Med Chem Lett 7:482-6
Fitzgerald, Megan L; Kassir, Suham A; Underwood, Mark D et al. (2016) Dysregulation of Striatal Dopamine Receptor Binding in Suicide. Neuropsychopharmacology :
Keilp, John G; Stanley, Barbara H; Beers, Sue R et al. (2016) Further evidence of low baseline cortisol levels in suicide attempters. J Affect Disord 190:187-92
Melhem, Nadine M; Keilp, John G; Porta, Giovanna et al. (2016) Blunted HPA Axis Activity in Suicide Attempters Compared to those at High Risk for Suicidal Behavior. Neuropsychopharmacology 41:1447-56

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