PROJECT 3: SOCIAL COGNITION Social cognition refers to mental operations required for adaptive social functioning, Including perceiving, interpreting, and generating responses to the intentions, emotions, and behaviors of others. In the first grant period, we selected three behavioral measures that assess processes considered essential for meaningful communication, including relationship perception, Theory of Mind, and emotion processing. Prodromal, recent-onset, and chronic patients all performed significantly worse than their matched controls on these measures, with comparable effect sizes across illness phases. The next phase of this research program will extend findings from the first phase in several ways. First, we will look beyond static measures of social cognition and will test both social (facial affect perception) and non-social (problem solving) dynamic measures of malleability in response to brief intervention probes. Second, we wil evaluate the nature of the relationships among basic cognition, social cognition, and functional outcome using a subset of social cognitive measures from the current study. We will examine whether social cognitive measures explain unique variance in functional outcome beyond basic cognition as measured by the MCCB, and whether these measures serve as mediators between basic cognition and outcome. Third, going beyond the findings of short-term stability of performance, we will examine long-term stability on specific measures of social cognition after an average of 5 years. Fourth, we will assess recollection and familiarity of social stimuli with a newly developed version of the Remember-Know (R-K) paradigm. We will compare recollection versus familiarity indices for their relationships to outcome, and compare these results to a non-social R-K paradigm administered in the Memory Project. Despite receiving adequate treatment, many individuals with schizophrenia have problems in social communication and independent functioning. The proposed research will shed light on the developmental course and malleability of social cognitive deficits that impact functioning in schizophrenia. This information can inform the development of new treatments for social cognitive deficits that may improve community functioning in schizophrenia.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Specialized Center (P50)
Project #
Application #
Study Section
Special Emphasis Panel (ZMH1-ERB-N)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California Los Angeles
Los Angeles
United States
Zip Code
Tsai, Katherine H; López, Steve; Marvin, Sarah et al. (2015) Perceptions of family criticism and warmth and their link to symptom expression in racially/ethnically diverse adolescents and young adults at clinical high risk for psychosis. Early Interv Psychiatry 9:476-86
Nuechterlein, Keith H; Ventura, Joseph; Subotnik, Kenneth L et al. (2014) Developing a Cognitive Training Strategy for First-Episode Schizophrenia: Integrating Bottom-Up and Top-Down Approaches. Am J Psychiatr Rehabil 17:225-253
McCleery, A; Ventura, J; Kern, R S et al. (2014) Cognitive functioning in first-episode schizophrenia: MATRICS Consensus Cognitive Battery (MCCB) Profile of Impairment. Schizophr Res 157:33-9
Nuechterlein, Keith H; Ventura, Joseph; Subotnik, Kenneth L et al. (2014) The early longitudinal course of cognitive deficits in schizophrenia. J Clin Psychiatry 75 Suppl 2:25-9
Hamilton, Holly K; Sun, Jane C; Green, Michael F et al. (2014) Social cognition and functional outcome in schizophrenia: The moderating role of cardiac vagal tone. J Abnorm Psychol 123:764-70
Ventura, Joseph; Subotnik, Kenneth L; Ered, Arielle et al. (2014) The relationship of attitudinal beliefs to negative symptoms, neurocognition, and daily functioning in recent-onset schizophrenia. Schizophr Bull 40:1308-18
Subotnik, Kenneth L; Ventura, Joseph; Gretchen-Doorly, Denise et al. (2014) The impact of second-generation antipsychotic adherence on positive and negative symptoms in recent-onset schizophrenia. Schizophr Res 159:95-100
Karlsgodt, Katherine H; van Erp, Theo G M; Bearden, Carrie E et al. (2014) Altered relationships between age and functional brain activation in adolescents at clinical high risk for psychosis. Psychiatry Res 221:21-9
Golembo-Smith, Shana; Bachman, Peter; Senturk, Damla et al. (2014) Youth-caregiver agreement on clinical high-risk symptoms of psychosis. J Abnorm Child Psychol 42:649-58
Ventura, Joseph; Reise, Steven P; Keefe, Richard S E et al. (2013) The Cognitive Assessment Interview (CAI): reliability and validity of a brief interview-based measure of cognition. Schizophr Bull 39:583-91

Showing the most recent 10 out of 72 publications