PROJECT 3: SOCIAL COGNITION Social cognition refers to mental operations required for adaptive social functioning, Including perceiving, interpreting, and generating responses to the intentions, emotions, and behaviors of others. In the first grant period, we selected three behavioral measures that assess processes considered essential for meaningful communication, including relationship perception, Theory of Mind, and emotion processing. Prodromal, recent-onset, and chronic patients all performed significantly worse than their matched controls on these measures, with comparable effect sizes across illness phases. The next phase of this research program will extend findings from the first phase in several ways. First, we will look beyond static measures of social cognition and will test both social (facial affect perception) and non-social (problem solving) dynamic measures of malleability in response to brief intervention probes. Second, we wil evaluate the nature of the relationships among basic cognition, social cognition, and functional outcome using a subset of social cognitive measures from the current study. We will examine whether social cognitive measures explain unique variance in functional outcome beyond basic cognition as measured by the MCCB, and whether these measures serve as mediators between basic cognition and outcome. Third, going beyond the findings of short-term stability of performance, we will examine long-term stability on specific measures of social cognition after an average of 5 years. Fourth, we will assess recollection and familiarity of social stimuli with a newly developed version of the Remember-Know (R-K) paradigm. We will compare recollection versus familiarity indices for their relationships to outcome, and compare these results to a non-social R-K paradigm administered in the Memory Project. Despite receiving adequate treatment, many individuals with schizophrenia have problems in social communication and independent functioning. The proposed research will shed light on the developmental course and malleability of social cognitive deficits that impact functioning in schizophrenia. This information can inform the development of new treatments for social cognitive deficits that may improve community functioning in schizophrenia.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center (P50)
Project #
5P50MH066286-09
Application #
8497724
Study Section
Special Emphasis Panel (ZMH1-ERB-N)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
9
Fiscal Year
2013
Total Cost
$177,295
Indirect Cost
$62,168
Name
University of California Los Angeles
Department
Type
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Ventura, Joseph; Subotnik, Kenneth L; Ered, Arielle et al. (2016) Cognitive Assessment Interview (CAI): Validity as a co-primary measure of cognition across phases of schizophrenia. Schizophr Res 172:137-42
Cannon, Tyrone D; Yu, Changhong; Addington, Jean et al. (2016) An Individualized Risk Calculator for Research in Prodromal Psychosis. Am J Psychiatry 173:980-988
Moskow, Danielle M; Addington, Jean; Bearden, Carrie E et al. (2016) The relations of age and pubertal development with cortisol and daily stress in youth at clinical risk for psychosis. Schizophr Res 172:29-34
Miller, Gregory A; Rockstroh, Brigitte S; Hamilton, Holly K et al. (2016) Psychophysiology as a core strategy in RDoC. Psychophysiology 53:410-4
Buchy, Lisa; Mathalon, Daniel H; Cannon, Tyrone D et al. (2016) Relation between cannabis use and subcortical volumes in people at clinical high risk of psychosis. Psychiatry Res 254:3-9
Deighton, Stephanie; Buchy, Lisa; Cadenhead, Kristin S et al. (2016) Traumatic brain injury in individuals at clinical high risk for psychosis. Schizophr Res 174:77-81
McLaughlin, Danielle; Carrión, Ricardo E; Auther, Andrea M et al. (2016) Functional Capacity Assessed by the Map Task in Individuals at Clinical High-Risk for Psychosis. Schizophr Bull 42:1234-42
Piskulic, Danijela; Liu, Lu; Cadenhead, Kristin S et al. (2016) Social cognition over time in individuals at clinical high risk for psychosis: Findings from the NAPLS-2 cohort. Schizophr Res 171:176-81
Stone, William S; Mesholam-Gately, Raquelle I; Giuliano, Anthony J et al. (2016) Healthy adolescent performance on the MATRICS Consensus Cognitive Battery (MCCB): Developmental data from two samples of volunteers. Schizophr Res 172:106-13
Owens, Emily M; Bachman, Peter; Glahn, David C et al. (2016) Electrophysiological Endophenotypes for Schizophrenia. Harv Rev Psychiatry 24:129-47

Showing the most recent 10 out of 121 publications