CORE 3: FUNCTIONAL OUTCOME AND SYMPTOM ASSESSMENT The primary goal of this Core (FOSAC) is to provide specialized training and quality assurance procedtires for assessing functional outcome, insight, diagnosis, and psychiatric symptoms to projects and cores within the Center. FOSAC will train raters to assess patients across 3 phases of illness in the Prodromal Project, the Aftercare Core, and the Chronic Core. FOSAC will be responsible for establishing and maintaining high levels of interrater reliability, preventing rater drift, and improving the reliability and validity of Center measures. To accomplish these goals, FOSAC will: 1) maintain well-standardized, and comprehensive training and quality assurance methods for assessing functional outcome, insight, prodromal signs, diagnosis of DSM-IV disorders, and psychiatric symptoms, 2) maintain reliability standards and criteria for certification of raters who use assessment instruments such as the CAF, MODSAS, GSRFS, SUMD-R, SCID-I, SCID-II, SIPS, BPRS, SANS, and SAPS, 3) ensure high levels of interrater reliability for trainers who will be conducting assessment procedures, and 4) expand FOSAC training videotape library to include updated training interviews. Phase 1 of training requires the rating of a minimum of 6 training videotapes and having interrater reliability calculated using the accompanying """"""""Gold Standard"""""""" consensus ratings. For categorical ratings, a minimum overall kappa is required of .80 (kappa sensitivity of .80 and kappa specificity of .80). For dimensional ratings, the trainee is required to achieve a minimum Interdass Correlation Coefficient (ICC) of .80. These requirements must be met before progressing to Phase 2 which requires thatthe rater conduct 4 """"""""live"""""""" assessments for each measure. In Phase 2, the FOSAC will formally evaluate the interviewer's ability to conduct the interview. If the requirements arenotmet, the trainee will be required to attend remediation sessions before """"""""graduating"""""""" to Phase 2. All raters will enter Phase 3, a QA Program aimed at preventing rater """"""""drift"""""""" FOSAC will collaborate with other Cores for Clinical Samples and Projects around research questions such as instrument development, method development, and improving interrater reliability.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Specialized Center (P50)
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Special Emphasis Panel (ZMH1-ERB-N)
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University of California Los Angeles
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Ventura, Joseph; Subotnik, Kenneth L; Ered, Arielle et al. (2016) Cognitive Assessment Interview (CAI): Validity as a co-primary measure of cognition across phases of schizophrenia. Schizophr Res 172:137-42
Cannon, Tyrone D; Yu, Changhong; Addington, Jean et al. (2016) An Individualized Risk Calculator for Research in Prodromal Psychosis. Am J Psychiatry 173:980-988
Moskow, Danielle M; Addington, Jean; Bearden, Carrie E et al. (2016) The relations of age and pubertal development with cortisol and daily stress in youth at clinical risk for psychosis. Schizophr Res 172:29-34
Miller, Gregory A; Rockstroh, Brigitte S; Hamilton, Holly K et al. (2016) Psychophysiology as a core strategy in RDoC. Psychophysiology 53:410-4
Buchy, Lisa; Mathalon, Daniel H; Cannon, Tyrone D et al. (2016) Relation between cannabis use and subcortical volumes in people at clinical high risk of psychosis. Psychiatry Res 254:3-9
Deighton, Stephanie; Buchy, Lisa; Cadenhead, Kristin S et al. (2016) Traumatic brain injury in individuals at clinical high risk for psychosis. Schizophr Res 174:77-81
McLaughlin, Danielle; Carrión, Ricardo E; Auther, Andrea M et al. (2016) Functional Capacity Assessed by the Map Task in Individuals at Clinical High-Risk for Psychosis. Schizophr Bull 42:1234-42
Piskulic, Danijela; Liu, Lu; Cadenhead, Kristin S et al. (2016) Social cognition over time in individuals at clinical high risk for psychosis: Findings from the NAPLS-2 cohort. Schizophr Res 171:176-81
Stone, William S; Mesholam-Gately, Raquelle I; Giuliano, Anthony J et al. (2016) Healthy adolescent performance on the MATRICS Consensus Cognitive Battery (MCCB): Developmental data from two samples of volunteers. Schizophr Res 172:106-13
Owens, Emily M; Bachman, Peter; Glahn, David C et al. (2016) Electrophysiological Endophenotypes for Schizophrenia. Harv Rev Psychiatry 24:129-47

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