Positive affect improves, but depression impairs, performance on tasks of executive function (Levin et al., in press). Extreme emotions are not necessary for these effects: even mild conditions of positive affect or feeling down have observable influences on the way in which people process information. We have argued that the mechanism of these effects depends on emotion-dependent changes in regional brain activity that either enhance or impair performance, depending on the role that a particular brain region plays in the implementation of a task. To date, however, there has been no systematic evaluation of the impact of specific emotional states on executive function, nor has there been an assessment of the brain activity involved. The present project, based at U. Illinois, will examine both state and trait contributions of emotion to executive function and has two specific aims. In the first, the effects of state emotion on brain activity will be assessed by inducing mood measuring fMRI during the color-word Stroop task. Our model of regional brain activity during emotional processing will be integrated with Banich's cascade model of attentional control. In addition, we will examine the effect of simulated emotional states on the computational model developed in Project 1.
The second aim i s to integrate our model of brain organization for different emotions with U. Colorado colleagues'model delineating subcomponents of executive function (inhibition, shifting, and updating). Neuroimaging findings suggest that there are both common and distinct neural networks involved across the domains (Collette et al., 2005). Activity in these same neural networks has been implicated in our models of emotional experience and regulation. These data suggest that different emotions may be asssociated with distinct patterns of impaired or enhanced executive function. The focus of Aim 2 is to examine the influence of trait emotion on executive function by selecting people who score high on affective dimensions that we have shown to be associated with distinct patterns of brain activity as measured by fMRI and ERPs. Understanding the ways that both state and trait affect might influence cognitive processes and associated patterns of brain activity will provide insight into common everyday experiences as well as emotion/cognition interactions associated with individual differences in personality traits that might be related to current or future depressive episodes.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center (P50)
Project #
5P50MH079485-05
Application #
8378644
Study Section
Special Emphasis Panel (ZMH1-ERB-H)
Project Start
Project End
Budget Start
2012-02-01
Budget End
2013-01-31
Support Year
5
Fiscal Year
2012
Total Cost
$181,090
Indirect Cost
Name
University of Colorado at Boulder
Department
Type
DUNS #
007431505
City
Boulder
State
CO
Country
United States
Zip Code
80309
Benca, Chelsie E; Derringer, Jaime L; Corley, Robin P et al. (2017) Predicting Cognitive Executive Functioning with Polygenic Risk Scores for Psychiatric Disorders. Behav Genet 47:11-24
Pauli, Wolfgang M; O'Reilly, Randall C; Yarkoni, Tal et al. (2016) Regional specialization within the human striatum for diverse psychological functions. Proc Natl Acad Sci U S A 113:1907-12
Reineberg, Andrew E; Banich, Marie T (2016) Functional connectivity at rest is sensitive to individual differences in executive function: A network analysis. Hum Brain Mapp 37:2959-75
Burdwood, Erin N; Infantolino, Zachary P; Crocker, Laura D et al. (2016) Resting-state functional connectivity differentiates anxious apprehension and anxious arousal. Psychophysiology 53:1451-9
Bredemeier, Keith; Warren, Stacie L; Berenbaum, Howard et al. (2016) Executive function deficits associated with current and past major depressive symptoms. J Affect Disord 204:226-33
Depue, B E; Orr, J M; Smolker, H R et al. (2016) The Organization of Right Prefrontal Networks Reveals Common Mechanisms of Inhibitory Regulation Across Cognitive, Emotional, and Motor Processes. Cereb Cortex 26:1634-1646
Barker, Jane E; Munakata, Yuko (2015) Time Isn't of the Essence: Activating Goals Rather Than Imposing Delays Improves Inhibitory Control in Children. Psychol Sci 26:1898-908
Smolker, H R; Depue, B E; Reineberg, A E et al. (2015) Individual differences in regional prefrontal gray matter morphometry and fractional anisotropy are associated with different constructs of executive function. Brain Struct Funct 220:1291-306
Banich, Marie T; Mackiewicz Seghete, Kristen L; Depue, Brendan E et al. (2015) Multiple modes of clearing one's mind of current thoughts: overlapping and distinct neural systems. Neuropsychologia 69:105-17
Kaiser, Roselinde H; Andrews-Hanna, Jessica R; Spielberg, Jeffrey M et al. (2015) Distracted and down: neural mechanisms of affective interference in subclinical depression. Soc Cogn Affect Neurosci 10:654-63

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