This Project investigates how the brain computes the values that rewards have for other people. While the prior two Projects study social decision-making that is based on the value that stimuli have for the person making the decision, this Project 3 studies decisions about the values rewards have for another person. Examples include altruistic behaviors, such as sacrificing food for a child or giving a donation to charity, but also encompass strategic and manipulative behaviors, such as a car salesman's need to figure out how much a customer might value a used car. These abilities are related to empathy and theory-of-mind, likely rare in other animals, and feature pronounced individual differences that can merge into pathology in mental illnesses such as autism. This Project will use the same computational framework as in Project 1, dissecting the neural signals that correlate with the value of decisions benefiting others at the time of choice, and with the values of the outcomes of those decisions (seeing somebody else get a benefit as a consequence of your decision). Only a handful of studies have addressed this topic, yet like the observational learning topic of Project 2 it is ubiquitous in human behavior. This Project continues our multimodal approach, using both fMRI and electrophysiological recordings, and investigating both humans and monkeys.
Two Specific Aims compare the neural mechanisms behind processing decision values and experienced values for oneself, or for another person.
A third Aim i nvestigates how these mechanisms may be modulated by social context: if the other person is a stranger or familiar, or if they are judged to be deserving or not, and if the subject herself is being watched by others or not. A final fourth Aim leverages the data from Core 3 in an exploratory investigation of individual differences.

Public Health Relevance

Many mental illnesses are associated with the most disabling dysfunction in the social domain. In terms of the processes investigated in this Project 3, these are thought to be abnormal in diseases such as fronto-temporal dementia, autism, and psychopathy. This Project will have relevance for the ultimate diagnosis, management and treatment of such disorders.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center (P50)
Project #
5P50MH094258-03
Application #
8661297
Study Section
Special Emphasis Panel (ZMH1)
Project Start
Project End
Budget Start
2014-05-01
Budget End
2015-04-30
Support Year
3
Fiscal Year
2014
Total Cost
Indirect Cost
Name
California Institute of Technology
Department
Type
DUNS #
City
Pasadena
State
CA
Country
United States
Zip Code
91125
Yao, Shuxia; Qi, Song; Kendrick, Keith M et al. (2018) Attentional set to safety recruits the ventral medial prefrontal cortex. Sci Rep 8:15395
Schneider, Brett; Heskje, Jonah; Bruss, Joel et al. (2018) The left temporal pole is a convergence region mediating the relation between names and semantic knowledge for unique entities: Further evidence from a ""recognition-from-name"" study in neurological patients. Cortex 109:14-24
Folkerts, Sarah; Rutishauser, Ueli; Howard, Marc W (2018) Human Episodic Memory Retrieval Is Accompanied by a Neural Contiguity Effect. J Neurosci 38:4200-4211
Cameron, C Daryl; Reber, Justin; Spring, Victoria L et al. (2018) Damage to the ventromedial prefrontal cortex is associated with impairments in both spontaneous and deliberative moral judgments. Neuropsychologia 111:261-268
Mobbs, Dean; Trimmer, Pete C; Blumstein, Daniel T et al. (2018) Foraging for foundations in decision neuroscience: insights from ethology. Nat Rev Neurosci :
Feng, Chunliang; Cao, Jianqin; Li, Yingli et al. (2018) The pursuit of social acceptance: aberrant conformity in social anxiety disorder. Soc Cogn Affect Neurosci 13:809-817
Qi, Song; Hassabis, Demis; Sun, Jiayin et al. (2018) How cognitive and reactive fear circuits optimize escape decisions in humans. Proc Natl Acad Sci U S A 115:3186-3191
Chib, Vikram S; Adachi, Ryo; O'Doherty, John P (2018) Neural substrates of social facilitation effects on incentive-based performance. Soc Cogn Affect Neurosci :
Barrash, Joseph; Stuss, Donald T; Aksan, Nazan et al. (2018) ""Frontal lobe syndrome""? Subtypes of acquired personality disturbances in patients with focal brain damage. Cortex 106:65-80
Beadle, Janelle N; Paradiso, Sergio; Tranel, Daniel (2018) Ventromedial Prefrontal Cortex Is Critical for Helping Others Who Are Suffering. Front Neurol 9:288

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