This core will provide integrative services for administration, human resources, and data analysis. For administration, this core will have the following roles: 1) provision of a centralized administrative facility for the entire center, including financial administration, organization of human and animal subject protocols, and coordination of research meetings inside this center;2) scientific leadership to the entire center by organizing scientific issues towards uniform goals, coordinating collaborative research and material exchange with investigators outside the center (resource/data sharing), and communicating with advisory committees and board;3) training programs for young investigators and a summer undergraduate course;and 4) public outreach for both lay persons and scientific peers outside of the center. For human resources, this core will connect two established groups keeping world-class repositories of human genetic and tissue samples together with detailed clinical data. For data analyses, this core will provide consultation for experiments and data analyses, including microarray studies (gene expression profiling) and genetic sequencing. These data will be centrally analyzed together with currently available datasets in human tissue/genetic resources. This core will closely work with Core B for overall data analysis. Finally, this core will provide services for database production.

Public Health Relevance

To achieve a multifaceted and translational approach we propose the integration of well-established repositories of human genetic and tissue samples with several hypotheses-driven preclinical projects. In addition, a central structure that can also link to a well established animal behavioral facility (Core B) is proposed.

Agency
National Institute of Health (NIH)
Type
Specialized Center (P50)
Project #
5P50MH094268-04
Application #
8681530
Study Section
Special Emphasis Panel (ZMH1)
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Type
DUNS #
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Severance, Emily G; Gressitt, Kristin L; Stallings, Cassie R et al. (2016) Probiotic normalization of Candida albicans in schizophrenia: A randomized, placebo-controlled, longitudinal pilot study. Brain Behav Immun :
Saylor, Deanna; Dickens, Alex M; Sacktor, Ned et al. (2016) HIV-associated neurocognitive disorder--pathogenesis and prospects for treatment. Nat Rev Neurol 12:234-48
Severance, Emily G; Gressitt, Kristin L; Stallings, Catherine R et al. (2016) Candida albicans exposures, sex specificity and cognitive deficits in schizophrenia and bipolar disorder. NPJ Schizophr 2:16018
Severance, Emily G; Yolken, Robert H; Eaton, William W (2016) Autoimmune diseases, gastrointestinal disorders and the microbiome in schizophrenia: more than a gut feeling. Schizophr Res 176:23-35
Saito, A; Taniguchi, Y; Rannals, M D et al. (2016) Early postnatal GABAA receptor modulation reverses deficits in neuronal maturation in a conditional neurodevelopmental mouse model of DISC1. Mol Psychiatry 21:1449-59
Katsanis, Nicholas (2016) The continuum of causality in human genetic disorders. Genome Biol 17:233
Tankou, Stephanie; Ishii, Kazuhiro; Elliott, Christina et al. (2016) SUMOylation of DISC1: a potential role in neural progenitor proliferation in the developing cortex. Mol Neuropsychiatry 2:20-27
Macpherson, Tom; Morita, Makiko; Wang, Yanyan et al. (2016) Nucleus accumbens dopamine D2-receptor expressing neurons control behavioral flexibility in a place discrimination task in the IntelliCage. Learn Mem 23:359-64
Koh, Ming Teng; Shao, Yi; Sherwood, Andrew et al. (2016) Impaired hippocampal-dependent memory and reduced parvalbumin-positive interneurons in a ketamine mouse model of schizophrenia. Schizophr Res 171:187-94
Owen, Michael J; Sawa, Akira; Mortensen, Preben B (2016) Schizophrenia. Lancet 388:86-97

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