Previous research suggested that earlier intervention may contribute to better outcomes in autism. Answering the question """"""""how early?"""""""" has significant health and educational implications for age of screening and age of entry into early intervention for children with autism spectrum disorders (ASD). With the increased number of young children identified with ASD, there is a pressing need for evidence-based, manualized cost-efficient treatments that are accessible to and feasibly implemented by parents within their natural environments in community-based settings. Significant disparities in diagnosis and treatment of ASD have been found in racial and ethnic minority populations increasing the need for families from diverse cultural and socioeconomic backgrounds. The major objective of Project 3 is to directly compare two parent intervention conditions of the Early Social Interaction Project for 9 months on developmental trajectories of infants showing early risk for ASD. The control treatment is an information, education and support group (IES) offered weekly;the experimental treatment is a parent-implemented intervention (Pll) offered in 2 weekly individualized sessions to teach parents how to embed strategies to support social communication skills within everyday routines, activities, and places, in combination with IES. Project 3 will recruit 92 parent-infant dyads at 12 months of age from the high risk siblings being studied in the Emory ACE Center. High risk infants will screen positive on 2 of 3 screening measures indicating the presence of diagnostic features of ASD by 12 months of age. Families will be randomly assigned to either IES or lES+PII for 9 months.
The specific aims of this investigation are:
Aim 1) Effectiveness of Treatment- to compare the effectiveness of IES plus Pll on developmental trajectories of social communication, autism symptoms, social visual engagement, developmental skills, and adaptive behavior, compared to IES alone;
Aim 2) Mediators of Treatment- to determine whether growth trajectories of child active engagement and parent transactional support are mediators of response to intervention;
and Aim 3) Moderators of Treatment: - to identify individual child and family characteristics which predict response to intervention.

Public Health Relevance

This impact of this study will: 1) document improved outcomes for very young children with ASD receiving a manualized, community-based, cost efficient, appropriate, and effective intervention;and 2) substantiate that individualized intervention beginning by 12 months of age leads to better outcomes, providing evidence that early detection of autism is crucial to enable access to early intervention.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Specialized Center (P50)
Project #
Application #
Study Section
Special Emphasis Panel (ZHD1-DSR-Y)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Emory University
United States
Zip Code
Lyu, Ilwoo; Kim, Sun H; Seong, Joon-Kyung et al. (2015) Robust estimation of group-wise cortical correspondence with an application to macaque and human neuroimaging studies. Front Neurosci 9:210
Klin, Ami; Shultz, Sarah; Jones, Warren (2015) Social visual engagement in infants and toddlers with autism: early developmental transitions and a model of pathogenesis. Neurosci Biobehav Rev 50:189-203
Klin, Ami; Wetherby, Amy M; Woods, Juliann et al. (2015) Toward innovative, cost-effective, and systemic solutions to improve outcomes and well-being of military families affected by autism spectrum disorder. Yale J Biol Med 88:73-9
Cherel, Marie; Budin, Francois; Prastawa, Marcel et al. (2015) Automatic Tissue Segmentation of Neonate Brain MR Images with Subject-specific Atlases. Proc SPIE Int Soc Opt Eng 9413:
Klin, Ami; Klaiman, Cheryl; Jones, Warren (2015) Reducing age of autism diagnosis: developmental social neuroscience meets public health challenge. Rev Neurol 60 Suppl 1:S3-11
Oguz, Ipek; Styner, Martin; Sanchez, Mar et al. (2015) LOGISMOS-B for Primates: Primate Cortical Surface Reconstruction and Thickness Measurement. Proc SPIE Int Soc Opt Eng 9413:
Chawarska, Katarzyna; Shic, Frederick; Macari, Suzanne et al. (2014) 18-month predictors of later outcomes in younger siblings of children with autism spectrum disorder: a baby siblings research consortium study. J Am Acad Child Adolesc Psychiatry 53:1317-1327.e1
Gao, Hao; Li, Longchuan; Zhang, Kai et al. (2014) PCLR: phase-constrained low-rank model for compressive diffusion-weighted MRI. Magn Reson Med 72:1330-41
Lyu, Ilwoo; Kim, Sun Hyung; Seong, Joon-Kyung et al. (2013) Group-wise cortical correspondence via sulcal curve-constrained entropy minimization. Inf Process Med Imaging 23:364-75
Li, Longchuan; Hu, Xiaoping; Preuss, Todd M et al. (2013) Mapping putative hubs in human, chimpanzee and rhesus macaque connectomes via diffusion tractography. Neuroimage 80:462-74

Showing the most recent 10 out of 11 publications