Ten years of pioneering research capitalizing on eye-tracking technology to measure spontaneous visual scanning behavior in viewing of naturalistic situations have demonstrated that infants at risk of developing autism spectrum disorders (ASD) display atypical patterns of visual attention in the first year of life, a period when social engagement with faces is crucial for the transition to spoken language. Expanding our programmatic effort in the Emory ACE to track the ontogeny of social engagement and its derailment in autism. Project II will map out the developmental unfolding of social vocal engagement over the first three years of life, to explore the consequences of eariy derailment of social visual engagement investigated in Project I. By tracking the development of spoken language in Project II concurrently with eye-tracking measures of visual attention to talking faces in Project I from 2 to 36 months in a cohort of 235 infants with ASD, non-autistic developmental delays (DD) and typical development (TD), the close synergy between these two projects will shed light on the relationship between two core deficits defining ASD, as well as suggesting mechanisms for targeted eariy intervention exploited in Project III. The goal of Project II is to test the hypothesis that the derailment of emerging communication in infants at risk of autism can be attributed to an eariier breakdown in mechanisms of social engagement.
The first aim i s to quantify eariy vocal behavior and spoken language development in TD, DD, and ASD infants, based on automated acoustic analysis of day-long audio recordings of each child's language environment collected at monthly intervals from 2-36 months in the home.
The second aim i s to determine the relationship between social engagement in the first year of life and spoken language development in the first three years of life.
The third aim i s to determine whether developmental profiles for quantitative measures of visual attention (using eye-tracking measures) and spoken language development (using acoustic measures) within the first two years of life can together be used as: (a) categorical diagnostic markers;(b) predictors of autistic symptomatology;(c) a means of defining endophenotypes within the autism spectrum, linking risk, diagnosis and outcome.

Public Health Relevance

This research project will shed light on the relationship between two core deficits in ASD by determining how social engagement within the first year of life influences later spoken language development, and will help to guide the development of interventions that target the communication deficit in autism, addressing three key themes in the NIH Interagency Autism Committee Strategic Plan: Eariier Detection, Prevention, and Heterogeneity.

National Institute of Health (NIH)
Specialized Center (P50)
Project #
Application #
Study Section
Special Emphasis Panel (ZHD1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Emory University
United States
Zip Code
Klin, Ami; Shultz, Sarah; Jones, Warren (2015) Social visual engagement in infants and toddlers with autism: early developmental transitions and a model of pathogenesis. Neurosci Biobehav Rev 50:189-203
Gao, Hao; Li, Longchuan; Zhang, Kai et al. (2014) PCLR: phase-constrained low-rank model for compressive diffusion-weighted MRI. Magn Reson Med 72:1330-41
Li, Longchuan; Hu, Xiaoping; Preuss, Todd M et al. (2013) Mapping putative hubs in human, chimpanzee and rhesus macaque connectomes via diffusion tractography. Neuroimage 80:462-74