Our broad goal is to understand the complex developmental relationships between language and affect, two expressive human systems for communication. This project will chart the neuro-developmental trajectories of the cognitive domains of language, affect and discourse in normal and experimental population: children with unilateral Focal Lesions, (FL) Language Impairment (LI), Autism (AUT) and two genetically based forms of mental retardation, Williams Syndrome (WMS) and Down Syndrome (DNS). This project provides a clearly-defined forum for the investigation of cross-population hypotheses with respect to the development and integration of these two communicative systems. This project will serve as a center for measures of language development in narrative discourse and experimental language tests this project will also will break new ground in characterizing affective development across childhood as an independent system, and in relation to linguistic communication in a discourse context. Our initial findings are intriguing, and raise fundamental issues about the neuroanatomical organization of language and affect of their interface in children. In adults, affect is predominantly a right hemisphere function whereas language is mediated by the left hemisphere. This raises the following fundamental issues: To what degree is there re-organization and compensation in children: What is the course of development in the face of differential language deficits? To what extent do the trajectories of our atypical populations map onto or dissociate from normal; To explore these issues, we propose a comprehensive and hypothesis driven battery of experimental tasks. Our overall goal is three=-pronged; To understand the functional relationships and underlying neural substrates of effect and discourse, To map our developmental changes within and between these two communicative domains across the period from 5 years to adolescence, and To characterize and contrast normal developmental profiles with those that are observed in our experimental populations (FL, LI, WMS, DNS, AUT). Finally, cross-population studies will enable us to identify those elements which are dissociable within and across domains as well as address issues of localization of function and brain plasticity. Thus, in addition to its service functions ina the measurement of language development this project will address basic questions about the co-development of language and affective communication and their neural substrates. These studies have implications for diagnoses and interventions for a broad range of children with disorders of language and communication.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Specialized Center (P50)
Project #
5P50NS022343-12
Application #
6243566
Study Section
Project Start
1997-05-01
Project End
1998-04-30
Budget Start
1996-10-01
Budget End
1997-09-30
Support Year
12
Fiscal Year
1997
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Type
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Ng, Rowena; Lai, Philip; Brown, Timothy T et al. (2018) Neuroanatomical correlates of emotion-processing in children with unilateral brain lesion: A preliminary study of limbic system organization. Soc Neurosci 13:688-700
Stiles, Joan (2017) Principles of brain development. Wiley Interdiscip Rev Cogn Sci 8:
Jernigan, Terry L; Stiles, Joan (2017) Construction of the human forebrain. Wiley Interdiscip Rev Cogn Sci 8:
Fan, Chun Chieh; Brown, Timothy T; Bartsch, Hauke et al. (2017) Williams syndrome-specific neuroanatomical profile and its associations with behavioral features. Neuroimage Clin 15:343-347
Ng, Rowena; Brown, Timothy T; Järvinen, Anna M et al. (2016) Structural integrity of the limbic-prefrontal connection: Neuropathological correlates of anxiety in Williams syndrome. Soc Neurosci 11:187-92
Ng, Rowena; Brown, Timothy T; Erhart, Matthew et al. (2016) Morphological differences in the mirror neuron system in Williams syndrome. Soc Neurosci 11:277-88
Lai, Philip T; Reilly, Judy S (2015) Language and affective facial expression in children with perinatal stroke. Brain Lang 147:85-95
Webb, Sara Jane; Bernier, Raphael; Henderson, Heather A et al. (2015) Guidelines and best practices for electrophysiological data collection, analysis and reporting in autism. J Autism Dev Disord 45:425-43
Yousefian, Omid; Ballantyne, Angela O; Doo, Alex et al. (2015) Clock drawing in children with perinatal stroke. Pediatr Neurol 52:592-8
Polse, Lara R; Reilly, Judy S (2015) Orthographic and semantic processing in young readers. J Res Read 38:47-72

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