Narcolepsy-cataplexy is a serious and chronic sleep disorder resulting in excessive daytime sleepiness and cataplexy. It is one of the most common neurological disorders, affecting approximately 1 in 2,000 individuals in North America. This multidisciplinary project focuses on the study of human narcolepsy and seeks to identify the genetic and environmental factors involved in triggering narcolepsy. We also want to understand why the immune system destroys hypocretin neurons in narcolepsy and to prevent/cure it.

Public Health Relevance

Narcolepsy-cataplexy is a serious and chronic sleep disorder resulting in excessive daytime sleepiness and cataplexy, and this project seeks to discover the factors involved in triggering human narcolepsy.

Agency
National Institute of Health (NIH)
Type
Specialized Center (P50)
Project #
5P50NS023724-27
Application #
8705034
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Program Officer
He, Janet
Project Start
Project End
Budget Start
Budget End
Support Year
27
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Stanford University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
City
Stanford
State
CA
Country
United States
Zip Code
94304
Mignot, Emmanuel J M (2014) History of narcolepsy at Stanford University. Immunol Res 58:315-39
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Moore 4th, Hyatt; Winkelmann, Juliane; Lin, Ling et al. (2014) Periodic leg movements during sleep are associated with polymorphisms in BTBD9, TOX3/BC034767, MEIS1, MAP2K5/SKOR1, and PTPRD. Sleep 37:1535-42
Goldbart, Aviv; Peppard, Paul; Finn, Laurel et al. (2014) Narcolepsy and predictors of positive MSLTs in the Wisconsin Sleep Cohort. Sleep 37:1043-51
Han, Fang; Lin, Ling; Schormair, Barbara et al. (2014) HLA DQB1*06:02 negative narcolepsy with hypocretin/orexin deficiency. Sleep 37:1601-8
Mahlios, Josh; De la Herran-Arita, Alberto K; Mignot, Emmanuel (2013) The autoimmune basis of narcolepsy. Curr Opin Neurobiol 23:767-73
Faraco, Juliette; Lin, Ling; Kornum, Birgitte Rahbek et al. (2013) ImmunoChip study implicates antigen presentation to T cells in narcolepsy. PLoS Genet 9:e1003270
Weiner Lachmi, Karin; Lin, Ling; Kornum, Birgitte Rahbek et al. (2012) DQB1*06:02 allele-specific expression varies by allelic dosage, not narcolepsy status. Hum Immunol 73:405-10
Zeitzer, Jamie M; Kodama, Tohru; Buckmaster, Christine L et al. (2012) Time-course of cerebrospinal fluid histamine in the wake-consolidated squirrel monkey. J Sleep Res 21:189-94
Han, Fang; Lin, Ling; Li, Jing et al. (2012) TCRA, P2RY11, and CPT1B/CHKB associations in Chinese narcolepsy. Sleep Med 13:269-72

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