Public Health Relevance

Narcolepsy-cataplexy is a serious and chronic sleep disorder resulting in excessive daytime sleepiness and cataplexy. It is one of the most common neurological disorders, affecting approximately 1 in 2,000 individuals in North America. Our research aims to understand the genetics of this disorder thus allowing for the development of better treatment (s) for this condifion.

National Institute of Health (NIH)
Specialized Center (P50)
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National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
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Stanford University
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Mignot, Emmanuel J M (2014) History of narcolepsy at Stanford University. Immunol Res 58:315-39
Warby, Simon C; Wendt, Sabrina L; Welinder, Peter et al. (2014) Sleep-spindle detection: crowdsourcing and evaluating performance of experts, non-experts and automated methods. Nat Methods 11:385-92
Moore 4th, Hyatt; Winkelmann, Juliane; Lin, Ling et al. (2014) Periodic leg movements during sleep are associated with polymorphisms in BTBD9, TOX3/BC034767, MEIS1, MAP2K5/SKOR1, and PTPRD. Sleep 37:1535-42
Goldbart, Aviv; Peppard, Paul; Finn, Laurel et al. (2014) Narcolepsy and predictors of positive MSLTs in the Wisconsin Sleep Cohort. Sleep 37:1043-51
Han, Fang; Lin, Ling; Schormair, Barbara et al. (2014) HLA DQB1*06:02 negative narcolepsy with hypocretin/orexin deficiency. Sleep 37:1601-8
Mahlios, Josh; De la Herran-Arita, Alberto K; Mignot, Emmanuel (2013) The autoimmune basis of narcolepsy. Curr Opin Neurobiol 23:767-73
Faraco, Juliette; Lin, Ling; Kornum, Birgitte Rahbek et al. (2013) ImmunoChip study implicates antigen presentation to T cells in narcolepsy. PLoS Genet 9:e1003270
Weiner Lachmi, Karin; Lin, Ling; Kornum, Birgitte Rahbek et al. (2012) DQB1*06:02 allele-specific expression varies by allelic dosage, not narcolepsy status. Hum Immunol 73:405-10
Zeitzer, Jamie M; Kodama, Tohru; Buckmaster, Christine L et al. (2012) Time-course of cerebrospinal fluid histamine in the wake-consolidated squirrel monkey. J Sleep Res 21:189-94
Han, Fang; Lin, Ling; Li, Jing et al. (2012) TCRA, P2RY11, and CPT1B/CHKB associations in Chinese narcolepsy. Sleep Med 13:269-72

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