Postmortem human brain tissue is essential for studies of the pathobiology and causes of Parkinson's disease (PD). The chief goal of the Clinical &Neuropathology Core (Core D) is to obtain and provide well-characterized postmortem human brain tissue for investigations of the etiology and basic mechanisms of Parkinson's disease (PD). These tissues are necessary to validate the hypotheses and observations generated by the studies of cellular and molecular biology and experimental animal models proposed in Projects 1-3. Core D clinical assessment protocols in concert with its neuropathological analyses and laboratory facilities enable acquisition of clinical data, brain tissue, and genetic material from the same subject and serve as powerful resources for validating findings from the Center's cellular and transgenic model studies. Accordingly, the staff of Core D recruits and follows clinically patients with PD and related disorders, as well as controls. These subjects give consent for eventual autopsy and brain donation and are enrolled in a prospective autopsy cohort. At death, the Core arranges and performs autopsies and provides neuropathological diagnoses in these subjects. Postmortem tissues are prepared and archived both for diagnostic and research purposes by the Brain Resource Center (BRC). The BRC serves as a repository of fixed and frozen brain tissues prepared for research including cases of PD, other Lewy body diseases, and normal and diseased controls. Core D also maintains and staffs histology, immunocytochemistry and stereology laboratories to support and facilitate the morphological assessment of human and experimental mouse models relevant to the studies of PD delineated in Projects 1-3. Finally, Core D provides the fundamental infrastructure to facilitate independently funded clinical and clinicopathological investigations of PD at JHMI and collaborating institutions and trains basic investigators and clinical neuroscientists in clinical and neuropathology issues relevant to PD.
The Clinical and Neuropathology Core serves as a resource for all of the research projects in the PD Center. Its main goal is to conduct clinical assessments and postmortem examination of patients with PD. The Core provides postmortem brain tissues to all of the Projects in the Hopkins PD Center and to investigators in other Udall Centers. The availability of these tissue samples is a critical step in the investigation of the causes and underlying mechanisms of PD.
|Mills, Kelly A; Mari, Zoltan; Bakker, Catherine et al. (2016) Gait function and locus coeruleus Lewy body pathology in 51 Parkinson's disease patients. Parkinsonism Relat Disord 33:102-106|
|Mao, Xiaobo; Ou, Michael Tianhao; Karuppagounder, Senthilkumar S et al. (2016) Pathological Î±-synuclein transmission initiated by binding lymphocyte-activation gene 3. Science 353:|
|Geiger, Joshua T; Arthur, Karissa C; Dawson, Ted M et al. (2016) C9orf72 Hexanucleotide Repeat Analysis in Cases with Pathologically Confirmed Dementia with Lewy Bodies. Neurodegener Dis 16:370-2|
|Mata, Ignacio F; Leverenz, James B; Weintraub, Daniel et al. (2016) GBA Variants are associated with a distinct pattern of cognitive deficits in Parkinson's disease. Mov Disord 31:95-102|
|Rosenthal, Liana S; Drake, Daniel; Alcalay, Roy N et al. (2016) The NINDS Parkinson's disease biomarkers program. Mov Disord 31:915-23|
|Jo, Junghyun; Xiao, Yixin; Sun, Alfred Xuyang et al. (2016) Midbrain-like Organoids from Human Pluripotent Stem Cells Contain Functional Dopaminergic and Neuromelanin-Producing Neurons. Cell Stem Cell 19:248-57|
|Karuppagounder, Senthilkumar S; Xiong, Yulan; Lee, Yunjong et al. (2016) LRRK2 G2019S transgenic mice display increased susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-mediated neurotoxicity. J Chem Neuroanat 76:90-97|
|Davis, Marie Y; Johnson, Catherine O; Leverenz, James B et al. (2016) Association of GBA Mutations and the E326K Polymorphism With Motor and Cognitive Progression in Parkinson Disease. JAMA Neurol 73:1217-1224|
|Nucifora Jr, Frederick C; Nucifora, Leslie G; Ng, Chee-Hoe et al. (2016) Ubiqutination via K27 and K29 chains signals aggregation and neuronal protection of LRRK2 by WSB1. Nat Commun 7:11792|
|Mills, Kelly A; Mari, Zoltan; Pontone, Gregory M et al. (2016) Cognitive impairment in Parkinson's disease: Association between patient-reported and clinically measured outcomes. Parkinsonism Relat Disord 33:107-114|
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